Actively Recruiting
Remote Ischemic Preconditioning and Postoperative Neuronal Injury
Led by University of Hamburg-Eppendorf · Updated on 2026-03-04
216
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative neuronal injury, as reflected by the maximum serum NfL concentration within the first 2 postoperative days, in non-cardiac surgery patients at risk for postoperative delirium.
CONDITIONS
Official Title
Remote Ischemic Preconditioning and Postoperative Neuronal Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 50 years or older scheduled for elective non-cardiac surgery with general anesthesia
- Patients at risk for postoperative delirium with at least two of the following: age 65 years or older, American Society of Anesthesiologists physical status classification of 3 or higher, Charlson Comorbidity, planned surgery longer than 180 minutes, regular use of more than five medications, symptoms of depression with Patient Health Questionnaire-9 score of 10 or higher
You will not qualify if you...
- Patients who cannot safely receive RIPC due to peripheral arterial disease (Fontaine stage 2 or higher), lymphedema, recent upper-arm surgery, trauma, or skin lesions on the arm
- Patients with acute coronary syndrome within the past month
- Patients who had surgery in the previous month
- Patients with intracranial surgery
- Patients with existing delirium
- Patients with severe cognitive impairment preventing delirium assessment
- Patients currently treated with sulfonamides
- Patients who previously participated in the SHIELD trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Medical Center Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
Research Team
A
Alina Bergholz
CONTACT
B
Bernd Saugel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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