Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT05830669

Remote Ischemic Preconditioning in Septic Patients

Led by Universität Münster · Updated on 2024-12-12

64

Participants Needed

1

Research Sites

138 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Acute kidney injury is a well-recognized complication in critically ill patients. Up to date there is no clinically established method to reduce the incidence or the severity of acute kidney injury. Remote ischemic preconditioning (RIPC) will be induced by three cycles of upper limb ischemia. The aim of the study is to reduce the incidence of AKI by implementing remote ischemic preconditioning (identified by the urinary biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7(IGFBP7)

CONDITIONS

Official Title

Remote Ischemic Preconditioning in Septic Patients

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients (age �3e=18 years)
  • Critically ill patients with sepsis less than 12 hours
  • Receiving invasive ventilation for at least 24 hours with propofol-free sedation and/or vasopressor therapy
  • Expected to receive unrestricted intensive care for at least 72 hours
  • Able to provide written informed consent
Not Eligible

You will not qualify if you...

  • Pre-existing acute kidney injury
  • Diagnosis of (glomerulo-)nephritis, interstitial nephritis, or vasculitis
  • Chronic kidney disease with estimated glomerular filtration rate less than 30 ml/min/1.73m�b2
  • Dependency on chronic dialysis
  • Kidney transplant within the last 12 months
  • Use of oral antidiabetics, sulfonamides, or nicorandil
  • Pregnancy or breastfeeding
  • Do-not-resuscitate order
  • Participation in another interventional trial involving kidney outcomes within the last 3 months
  • Dependency on the investigator or study center

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine

Münster, Germany, 48149

Actively Recruiting

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Research Team

M

Melanie Meersch-Dini, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

2

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