Actively Recruiting
Led by University of Oklahoma · Updated on 2026-05-01
38
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are investigating the effects of chemotherapy on cognitive function, often called "chemo-brain," in cancer survivors, especially those who also have type 2 diabetes (T2D). Chemotherapy can cause immune system disruptions and inflammation that damage brain blood vessels, which may lead to cognitive difficulties. Since T2D shares similar pathophysiological features, cancer survivors with T2D might experience greater cognitive impairments. This study aims to compare brain vascular, cognitive, inflammatory, and cardiometabolic outcomes between cancer survivors with and without T2D. Participants will take part in a 12-week physical activity program delivered remotely through two smartphone applications. This program includes aerobic and resistance exercises supported by a Fitbit activity tracker and resistance bands. The program is designed based on Social Cognitive Theory to promote both physical and psychological health improvements. The study includes 30 cancer survivors divided into two groups: 15 with T2D and 15 without, all self-reporting cognitive difficulties related to chemotherapy. Throughout the study, researchers will assess brain blood flow, vascular resistance, cognitive function, inflammatory markers, and cardiometabolic health at the start and after the 12-week program. Participants will be monitored using questionnaires and biological tests, including blood pressure, glucose levels, and inflammatory molecule concentrations. The study will evaluate how physical activity may impact these measures and improve quality of life for cancer survivors with and without T2D.
CONDITIONS
Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote or in-person) to confirm eligibility and collect baseline data
Duration - 12 weeks
Participants engage in a 12-week remotely delivered physical activity program based on Social Cognitive Theory designed to improve physiological and psychological health outcomes.
Weekly remote interactions via smartphone applications with continuous activity tracking using a Fitbit
Duration - Up to 2 weeks after the program ends
Participants complete post-program assessments to evaluate changes in cerebrovascular function, cognitive function, pro-inflammatory markers, cardiometabolic outcomes, and psychosocial metrics.
1 final remote or in-person visit for outcome assessments
Total: 1 location
1
University of Oklahoma Health Sciences
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
Z
Zachary C Pope, PhD
M
Mikhail Kellawan, PhD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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Zachary C Pope, Andriy Yabluchanskiy, Peter Mukli...
https://pubmed.ncbi.nlm.nih.gov/41370824