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Led by University of Oklahoma · Updated on 2026-05-01
38
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are investigating the effects of chemotherapy on cognitive function, often called chemo-brain, in cancer survivors, especially those who also have type 2 diabetes T2D. Chemotherapy can cause immune system disruptions and inflammation that damage brain blood vessels, which may lead to cognitive difficulties. Since T2D shares similar pathophysiological features, cancer survivors with T2D might experience greater cognitive impairments. This study aims to compare brain vascular, cognitive, inflammatory, and cardiometabolic outcomes between cancer survivors with and without T2D. Participants will take part in a 12-week physical activity program delivered remotely through two smartphone applications. This program includes aerobic and resistance exercises supported by a Fitbit activity tracker and resistance bands. The program is designed based on Social Cognitive Theory to promote both physical and psychological health improvements. The study includes 30 cancer survivors divided into two groups 15 with T2D and 15 without, all self-reporting cognitive difficulties related to chemotherapy. Throughout the study, researchers will assess brain blood flow, vascular resistance, cognitive function, inflammatory markers, and cardiometabolic health at the start and after the 12-week program. Participants will be monitored using questionnaires and biological tests, including blood pressure, glucose levels, and inflammatory molecule concentrations. The study will evaluate how physical activity may impact these measures and improve quality of life for cancer survivors with and without T2D.
CONDITIONS
Remote Physical Activity Programming to Improve Outcomes in Cancer Survivors With and Without Type 2 Diabetes
Z
Zachary C Pope, PhD
M
Mikhail Kellawan, PhD
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University of Oklahoma
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Remote App Exercise (Trial) | Usual Care (Contextual Comparator) |
|---|---|---|
| What it is | A 12-week, app-based physical activity program combining education, personalized aerobic and resistance training, goal-setting, online journaling, and activity tracking with a Fitbit, tailored for adult cancer survivors post-chemotherapy (with or without type 2 diabetes). | Standard post-chemotherapy survivorship care often includes general written or verbal recommendations to increase physical activity or to manage cognitive symptoms, without a structured or personalized digital program, apps, tracking tools, or remote health coaching. |
| Role in this study | All enrolled participants received the remote digital program. The study prospectively monitored outcomes before and after completing the 12-week course. | Not a direct part of the clinical trial. Usual care serves as an external comparison, reflecting what participants would likely have experienced outside the study. |
| Primary use in care | Designed to improve cognitive function, cerebrovascular health, and physiological outcomes in cancer survivors with or without type 2 diabetes, using tailored physical activity and behavioral support. | Standard survivorship care aims to help survivors maintain or improve their physical function and quality of life, and typically recommends regular physical activity, but relies on self-motivation without formal structure or remote supervision. |
| How it is given/performed | Delivered remotely over 12 weeks with two connected smartphone apps providing health education, individualized aerobic and resistance routines, goal-setting, journaling, and progress tracking. Participants were given a Fitbit and resistance bands for home use, with ongoing engagement via digital tools. | Physical activity recommendations are generally offered as advice during follow-up visits or in printed materials for self-directed action. No specific digital or remote supervision, personalized feedback, or provision of exercise equipment or fitness trackers. |
| Evidence status | Currently under investigation; no published clinical outcome results yet. Final effects on cognitive or physiological health for cancer survivors are not yet determined. | Regular exercise is supported by high-quality guidelines and clinical evidence for improving quality of life and function after cancer treatment. However, rates of structured activity adoption and adherence without dedicated programs remain low. |
| Important limitations | As a single-arm study, there is no internal trial comparator group, making it difficult to directly compare results against usual care. The program's success depends on participant engagement with remote technology, ability to use devices, and self-motivation. Ongoing results are pending. | Usual care generally lacks structured ongoing support, relies on survivors' initiative, and does not address common barriers like access to equipment, feedback, or behavioral help. Many survivors do not receive or follow through on physical activity advice alone. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (remote or in-person) to confirm eligibility and collect baseline data
Duration - 12 weeks
Participants engage in a 12-week remotely delivered physical activity program based on Social Cognitive Theory designed to improve physiological and psychological health outcomes.
Weekly remote interactions via smartphone applications with continuous activity tracking using a Fitbit
Duration - Up to 2 weeks after the program ends
Participants complete post-program assessments to evaluate changes in cerebrovascular function, cognitive function, pro-inflammatory markers, cardiometabolic outcomes, and psychosocial metrics.
1 final remote or in-person visit for outcome assessments
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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Zachary C Pope, Andriy Yabluchanskiy, Peter Mukli...
https://pubmed.ncbi.nlm.nih.gov/41370824/University of Oklahoma
Lead Sponsor
