Actively Recruiting
Remote Sputum Collection in Cystic Fibrosis
Led by University of Pennsylvania · Updated on 2025-10-01
150
Participants Needed
3
Research Sites
180 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
C
Cystic Fibrosis Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Elexacaftor/Tezacaftor/Ivacaftor or Trikafta improves lung health in people with cystic fibrosis (CF), including decreased cough and mucous production. Diagnosing lung infections has become more challenging due to the decrease in sputum and rise of telehealth services. While the option of collecting sputum samples at home and sending them by mail may be feasible, uncertainty remains about how the collection of samples outside of clinic and delays in testing while in the mail impact infection detection. This study will compare bacterial cultures using sputum samples collected at home versus samples collected in clinic (saline-induced sputum and throat swab). This study seeks to shed light on how valuable home collected samples can be and help us better understand the usefulness of home-collected sputum samples for both clinical and research purposes.
CONDITIONS
Official Title
Remote Sputum Collection in Cystic Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with cystic fibrosis based on CF Foundation guidelines including genetic testing, sweat chloride levels, or physician diagnosis
- Age 18 years or older
- Ability to comply with study visits and procedures as judged by the investigator
You will not qualify if you...
- Solid organ transplant recipients due to immunosuppression
- Unable to tolerate sputum induction with hypertonic saline or unable to attempt sputum expectoration
- No access to FedEx location or pick-up services for sending samples
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
National Jewish Health
Denver, Colorado, United States, 80206
Actively Recruiting
2
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Actively Recruiting
3
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
K
Krista Ludwig
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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