Actively Recruiting
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Led by Duke University · Updated on 2026-05-06
120
Participants Needed
5
Research Sites
192 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
E
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.
CONDITIONS
Official Title
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary diagnosis of COVID-19 requiring hospital admission
- Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)
- Able to ambulate with or without a gait aid prior to hospital discharge
- Age ≥ 18 years
You will not qualify if you...
-
Hospital discharge > 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge > 60 days
-
Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)
-
Functional impairment resulting in inability to exercise at baseline
-
Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction
-
Any absolute contraindications to exercise, including but not limited to:
- Recent (< 5 days) acute primary cardiac event
- Unstable Angina
- Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise
- Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure
- Symptomatic aortic stenosis
- Uncontrolled symptomatic heart failure
- Acute myocarditis or pericarditis
- Suspected or known dissecting aneurysm
-
Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure < 60 mmHg on 2 consecutive readings within 1 minute)
-
High risk for non-adherence as determined by screening evaluation
-
Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study
-
Pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
3
Duke University Health System
Durham, North Carolina, United States, 27710
Actively Recruiting
4
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States, 43201
Actively Recruiting
5
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37203
Actively Recruiting
Research Team
M
Marjan Cobbaert, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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