Actively Recruiting
Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Led by Shanghai University of Sport · Updated on 2026-04-14
68
Participants Needed
2
Research Sites
103 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment. The main questions it aims to answer are: 1. Does home-based TIS improve movement problems such as slow movement, stiffness, and walking difficulty? 2. Are the effects maintained after the treatment ends? 3. What medical problems (adverse events) occur during treatment? Researchers will compare active TIS to a sham treatment (a look-alike procedure that does not deliver active stimulation) to see if TIS works. Participants will: 1. Receive active TIS or sham stimulation once a day for 4 weeks at home under remote supervision 2. Visit the clinic at specific time points for movement assessments 3. Complete online questionnaires about symptoms and quality of life
CONDITIONS
Official Title
Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Parkinson's disease according to established clinical criteria
- Mild-to-moderate disease severity, defined as Hoehn and Yahr stage 1.5-3
- Age between 40 and 80 years
- Stable anti-parkinsonian medication regimen
- Ability to walk unaided for at least 2 minutes
You will not qualify if you...
- Contraindications to temporal interference stimulation such as metal implants or pacemakers
- Current use of deep brain stimulation (DBS)
- Significant cognitive impairment including Alzheimer's disease, dementia, or Montreal Cognitive Assessment (MoCA) score below 21
- Diagnosis of other neurological diseases such as multiple sclerosis or previous stroke
- Severe lower-extremity arthritis, pain, or orthopedic problems that affect walking
- Physician-diagnosed schizophrenia or other psychiatric illness
- Unwillingness to cooperate or participate in the study protocol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Shanghai University of Sport
Shanghai, Shanghai Municipality, China, 200438
Not Yet Recruiting
2
Shanghai University of Sport
Shanghai, Shanghai Municipality, China, 200438
Actively Recruiting
Research Team
Y
Yu Liu, Prof.
CONTACT
Z
Zijun Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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