Investigating the Benefits of Remotely-Supervised Neuromodulation In Primary Progressive Aphasia

What this Trial Is About

Researchers are studying adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder often linked to Alzheimer's disease, to see if combining remotely supervised brain stimulation with virtual speech-language therapy improves communication. The study aims to determine whether this combined treatment is feasible, acceptable, and more effective than speech therapy with placebo stimulation. It also explores if individual brain features can predict who benefits most from the therapy. Participants will be assigned randomly to receive either active or sham transcranial direct current stimulation (tDCS) alongside virtual speech-language therapy. The active tDCS involves 20-minute sessions of non-invasive brain stimulation delivered at home five times a week while engaging in computer-based speech training. The speech therapy includes two teletherapy sessions weekly plus independent practice exercises. Both treatment groups will be monitored remotely during sessions. Throughout the study, participants will complete language and cognitive tests before and after treatment, plus brain imaging and other evaluations to understand treatment effects. Researchers will measure changes in spoken naming ability at one and three months after treatment begins. Additional assessments include communication confidence, aphasia impact, and treatment acceptability. Participation involves regular video visits, remote supervision, and testing over several months.

Remotely-supervised Neuromodulation in PPA