Actively Recruiting
Remotely-supervised Neuromodulation in PPA
Led by Maya Henry · Updated on 2026-05-06
80
Participants Needed
2
Research Sites
172 weeks
Total Duration
On this page
Sponsors
M
Maya Henry
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease. The main questions the study aims to answer are: * Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA? * Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation? * Do individual brain characteristics help predict who benefits most from this treatment? Researchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes. Participants will: * Complete speech-language therapy sessions delivered by video visit. * Receive either active or sham tDCS that is remotely supervised and completed at home. * Complete language and cognitive testing before and after treatment. * Undergo brain imaging and other assessments to help understand treatment response.
CONDITIONS
Official Title
Remotely-supervised Neuromodulation in PPA
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets diagnostic criteria for primary progressive aphasia (PPA)
- Meets diagnostic criteria for logopenic variant PPA
- Scores 20 or higher on the Mini-Mental State Examination
- Has adequate hearing and vision (with aids if needed)
- Can travel to research site and undergo MRI brain scan
- Has access to high-speed internet and basic computer experience
- Is a fluent English speaker
- Has a study partner who can co-enroll, attend training, and join teleconference meetings
You will not qualify if you...
- Speech and language problems caused by another neurological disorder
- Does not meet diagnostic criteria for logopenic variant PPA
- Scores less than 20 on the Mini-Mental State Examination
- Does not have a study partner who can co-enroll
- Has contraindications for tDCS or MRI (such as seizures, head injury, skull surgery, migraines, metal implants, pacemaker, skin problems, or pregnancy)
- Has a history of stroke, epilepsy, or significant brain injury
AI-Screening
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Trial Site Locations
Total: 2 locations
1
UCSF Memory and Aging Cener
San Francisco, California, United States, 94158
Actively Recruiting
2
University of Texas
Austin, Texas, United States, 78712
Actively Recruiting
Research Team
A
Aphasia Lab Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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