Actively Recruiting
Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion
Led by University Medical Center Groningen · Updated on 2025-12-18
240
Participants Needed
3
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The REWARM study is a randomized controlled clinical efficacy study, with primary outcome renal function 12 months after transplantation of kidneys recovered from deceased donors aged 50 years or older. Prior to transplantation, kidney grafts in the intervention group will receive 6 hours of NMP, following standard HMP and kidneys in the control group will only receive standard treatment, being HMP. It is a multi-center trial. Given the total annual 50+ deceased donor kidney transplantation volume of the three participating transplant centers combined, inclusions in the study are expected to last 2.5-3 years, aiming for a total of 120 patients in each of the two arms (240 patients total).
CONDITIONS
Official Title
Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients receiving their first or second kidney transplant
- Patients receiving a graft from a 60-year-old donor
- Patients receiving a graft from a DCD or DBD donor
- Patients receiving a kidney transplant in the UMCG, the Erasmus MC, or the LUMC
- Patients receiving a graft stored on HMP
- Patients 60 years of age
- Patients having provided written informed consent
You will not qualify if you...
- Patients receiving their third or subsequent kidney transplant
- Patients receiving a graft from a donor < 50 years
- Patients receiving a graft not stored on HMP
- Patients receiving a graft from a donor that underwent normothermic regional perfusion (NRP)
- Patients receiving a kidney transplant in another center than the UMCG, Erasmus MC, or LUMC
- Patients receiving a multi-organ transplantation
- Patients receiving a kidney with complex arterial anatomy (3 or more arteries)
- Recipients < 18 years of age
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands
Actively Recruiting
2
Leiden University Medical Center
Leiden, Netherlands
Not Yet Recruiting
3
Erasmus Medical Center
Rotterdam, Netherlands
Actively Recruiting
Research Team
C
Cyril Moers, MD, PhD
CONTACT
K
Kirsten Ma, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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