Actively Recruiting
Renal Perfusion and the Development of AKI Following Traumatic Injury - A Longitudinal Observational Cohort Study
Led by King's College Hospital NHS Trust · Updated on 2025-04-08
20
Participants Needed
1
Research Sites
25 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how traumatic haemorrhagic shock (THS) affects kidney blood flow and the development of acute kidney injury (AKI), a serious complication that increases the risk of death. While past studies have shown that septic shock patients with severe AKI experience reduced blood flow in the kidney cortex, little is known about these changes in THS patients. This observational study aims to better understand the impact of THS on kidney microcirculation to improve patient outcomes. The study uses several advanced imaging devices to monitor kidney blood flow. These include contrast-enhanced ultrasound (CEUS), venous excess ultrasound (VExUS), echocardiography, sublingual incident dark field (IDF) videomicroscopy, and continuous measurement of urinary oxygen tension. Measurements will be taken at enrollment, 24 hours, and 48 hours after ICU admission to track changes in renal perfusion over time. Participants will be adults admitted to the ICU within 24 hours of traumatic injury who received blood products and had elevated lactate levels. Researchers will assess kidney perfusion using cortical mean transit time, perfusion index, wash-in rate, and urinary oxygen tension. These tests will help evaluate kidney function and blood flow changes during the critical first 48 hours. The study is led by King's College Hospital NHS Trust and runs until July 2026.
CONDITIONS
Brief Title
Renal Perfusion and the Development of AKI Following Traumatic Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Within 24 hours of ICU admission following traumatic injury
- Received any blood products during initial resuscitation
- Lactate > 2 mmol/l at any stage prior to study enrolment
You will not qualify if you...
- Known intolerance to Sonovue or any other ultrasound contrast agent
- Patients with un-survivable injuries or not expected to survive 24 hours where treatment intent is palliative
- Known chronic kidney disease stage 4 or end stage renal failure
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 48 hours
Participants undergo ultrasound, sublingual incident dark field videomicroscopy, and continuous urinary oxygen tension monitoring to assess renal perfusion following traumatic injury.
Assessments at enrollment, +24 hours, and +48 hours
Duration - Up to 48 hours following enrollment
Participants are observed for changes in urinary oxygen tension and kidney function after the initial diagnostic evaluations.
Continuous monitoring during the 48 hour study period
Trial Site Locations
Total: 1 location
1
King's College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
Research Team
S
Sam Hutchings
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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