Actively Recruiting
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
Led by Yuanjun Yang · Updated on 2024-08-19
114
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The incidence of Chronic kidney disease (CKD) is showing an upward trend, but the therapeutic effect of treatment is limited. Remote ischemic conditioning (RIC) has the potential to safeguard remote organs via the repeated application of brief ischemic stimuli. the aim of our study is to investigate whether RIC can protect the renal function in patients with CKD.
CONDITIONS
Official Title
The Renal Protective Effects of Remote Ischemic Preconditioning in Patients With Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with chronic kidney disease with eGFR of 15 ml/min/1.73m2 or higher
- 24-hour urine protein excretion less than or equal to 3.5 grams
- Signed informed consent form
You will not qualify if you...
- Diagnosis of nephrotic syndrome
- History of acute kidney injury
- Previous renal replacement therapy
- Potential medication changes during RIC or sham-RIC intervention
- History of diabetes or glycated hemoglobin greater than 8%
- Familial hypercholesterolemia (greater than 5.5 mmol/L) with high LDL (greater than 2.5 mmol/L)
- Contraindications to RIC such as vascular injury, soft tissue injury, fracture, infection, or peripheral vascular disease in both arms
- History of bleeding disorders, systemic bleeding, or low platelet count
- Cardiogenic embolism (atrial fibrillation) or severe arrhythmias, previous heart attack, or severe heart failure (NYHA Class III and IV)
- Uncontrolled high blood pressure (systolic ≥ 200 mmHg despite treatment)
- Respiratory failure, cancer, or autoimmune diseases
- Pregnancy or breastfeeding at enrollment or during the study
AI-Screening
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Trial Site Locations
Total: 1 location
1
chinese PLA general hospital
Beijing, Beijing Municipality, China, 100853
Actively Recruiting
Research Team
Y
Yisha Li, PhD
CONTACT
D
Dayang Xie, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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