Actively Recruiting
Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System
Led by Boston Scientific Corporation · Updated on 2026-05-05
376
Participants Needed
39
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The ReMATCH Study is a prospective, single arm, open label, multi-center, study utilizing the FARAPULSE PFA System, including the FARAWAVE and FARAPOINT PFA Catheters.
CONDITIONS
Official Title
Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older, or older if required by local law
- Single previous endocardial atrial fibrillation ablation procedure for paroxysmal or persistent atrial fibrillation including pulmonary vein isolation
- Documented diagnosis of persistent atrial fibrillation before or after the initial procedure
- Documented evidence of symptomatic atrial fibrillation recurrence at least 60 days after the initial procedure captured by an approved rhythm monitoring device
- Willing and able to provide informed consent
- Willing and able to participate in all follow-up assessments and testing at an approved clinical center
You will not qualify if you...
- Left atrial diameter ≥ 5.5 cm or left atrial volume > 100 ml if diameter not available
- Current atrial myxoma
- Pulmonary vein abnormalities, stenosis, or stenting (except common and middle pulmonary veins)
- Current left atrial thrombus
- History of sustained ventricular tachycardia or ventricular fibrillation
- Atrial fibrillation due to reversible causes such as electrolyte imbalance, thyroid disease, or alcohol
- Current or planned implantable cardioverter defibrillator, cardiac resynchronization therapy device, or implantable loop recorder (except LUX-Dx); pacemaker-dependent patients excluded
- Prior interatrial baffle, atrial septal patch, defect closure device, or recent left atrial appendage closure device (WATCHMAN excluded if implanted within 90 days)
- Presence of prosthetic heart valve, moderate to severe mitral valve stenosis or regurgitation, moderate to severe aortic stenosis
- Hypertrophic cardiomyopathy
- Inferior vena cava filter or inability to obtain vascular access
- Awaiting cardiac transplantation or surgery within 12 months
- Severe right ventricular dysfunction
- NYHA Class III or IV heart failure
- Left ventricular ejection fraction below 40% within past 12 months
- Uncontrolled hypertension (SBP >160 mmHg or DBP >95 mmHg)
- Body mass index over 45
- CHA2DS2-VASc score 5 or higher
- Recent (within 90 days) myocardial infarction, unstable angina, coronary intervention, cardiac surgery, heart failure hospitalization, pericarditis, gastrointestinal bleeding, stroke, thromboembolism, carotid intervention
- Uncontrolled diabetes (HbA1c >8.0%)
- Significant congenital heart disease, methemoglobinemia, or G6PD deficiency
- Solid organ or hematologic transplant or evaluation for transplant
- Diaphragmatic paralysis or paresis
- Severe lung disease, pulmonary hypertension, or oxygen requirement
- Renal insufficiency (eGFR <30) or dialysis history
- Active malignancy (except squamous cell carcinoma)
- Significant gastrointestinal problems
- Active systemic infection
- Use of phosphodiesterase inhibitors within 24 hours before ablation
- Allergy to nitroglycerin
- Coagulopathy or bleeding disorders
- Contraindication or unwillingness to use anticoagulation
- Pregnancy or planning pregnancy without medical birth control
- Health conditions preventing study participation or affecting results
- Unwillingness or inability to tolerate LUX-Dx ICM device
- Current participation in conflicting investigational studies
- Life expectancy less than one year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 39 locations
1
Mobile Infirmary Medical Center
Mobile, Alabama, United States, 36607
Actively Recruiting
2
Arrhythmia Research Group-Research Facility
Jonesboro, Arkansas, United States, 72401
Actively Recruiting
3
University of Southern California Hospital
Los Angeles, California, United States, 90033
Actively Recruiting
4
St. John's Regional Medical Center
Oxnard, California, United States, 93030
Actively Recruiting
5
Stanford University Medical Center
Stanford, California, United States, 94305
Actively Recruiting
6
South Denver Cardiology Associates, PC
Littleton, Colorado, United States, 80120
Actively Recruiting
7
HCA Florida Mercy Hospital
Miami, Florida, United States, 33133
Actively Recruiting
8
Naples Comprehensive Health
Naples, Florida, United States, 34102
Actively Recruiting
9
AdventHealth Orlando-Hospital
Orlando, Florida, United States, 32803
Not Yet Recruiting
10
Tampa General Hospital
Tampa, Florida, United States, 33606
Not Yet Recruiting
11
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
12
Memorial Health University Medical Center
Savannah, Georgia, United States, 31404
Actively Recruiting
13
St. Luke's Boise Medical Center
Boise, Idaho, United States, 83712
Actively Recruiting
14
Advocate Christ Medical Center-Hospital
Oak Lawn, Illinois, United States, 60453
Not Yet Recruiting
15
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
16
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
17
Southcoast Physicians Group
Fall River, Massachusetts, United States, 02720
Actively Recruiting
18
William Beaumont Hospital-Hospital
Royal Oak, Michigan, United States, 48073
Actively Recruiting
19
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
20
Virtua Health Inc.
Marlton, New Jersey, United States, 08053
Actively Recruiting
21
Lovelace Medical Center
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
22
Northwell Health
Manhasset, New York, United States, 11030
Actively Recruiting
23
Weill Cornell Medical University
New York, New York, United States, 10065
Actively Recruiting
24
Bethesda North Hospital
Cincinnati, Ohio, United States, 45242
Actively Recruiting
25
Ohio State University Medical Center
Columbus, Ohio, United States, 43210
Actively Recruiting
26
Oklahoma Heart Institute
Tulsa, Oklahoma, United States, 74104
Actively Recruiting
27
Trident Medical Center
Charleston, South Carolina, United States, 29406
Actively Recruiting
28
Texas Cardiac Arrhythmia Research
Austin, Texas, United States, 78705
Actively Recruiting
29
Christus Trinity Mother Frances Health System
Tyler, Texas, United States, 75701
Actively Recruiting
30
St. Mark's Hospital
Salt Lake City, Utah, United States, 84124
Actively Recruiting
31
Sentara Norfolk General Hospital
Norfolk, Virginia, United States, 23507
Actively Recruiting
32
John Hunter Hospital
New Lambton Heights, New South Wales, Australia, 606-8507
Actively Recruiting
33
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
34
St. Andrew's War Memorial Hospital
Brisbane, Queensland, Australia, 4001
Actively Recruiting
35
Victorian Heart Hospital
Clayton, Victoria, Australia, 3168
Actively Recruiting
36
The Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
37
The Alfred Hospital
Melbourne, Australia
Actively Recruiting
38
National Taiwan University Hospital
Taipei, Taiwan
Actively Recruiting
39
Taipei Veterans General Hospital
Taipei, Taiwan
Actively Recruiting
Research Team
K
Kristin Mathson
CONTACT
K
Kaitlyn Aldrich
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here