Study of Early Clinical Course and Long-Term Follow-Up in Adults with Intermediate-High Risk Pulmonary Embolism at Sahlgrenska University Hospital

What this Trial Is About

Researchers are studying pulmonary embolism PE, a serious heart and lung condition, focusing on patients with intermediate-high risk PE. The study aims to better understand the early course of this condition and how changes in tests like biomarkers, ECG, and echocardiography during the first 48 hours relate to patient outcomes. It also seeks to create a long-term follow-up system for all PE patients treated at Sahlgrenska University Hospital to improve care quality and outcomes. The study has two parts Cohort A includes hospitalized patients with intermediate-high risk PE who undergo repeated tests and monitoring during the first three days after diagnosis, including vital signs, echocardiography, ECG, blood tests, and oxygen or circulatory support if needed. Cohort B includes all PE patients diagnosed at the hospital, who are followed over time with baseline and follow-up assessments at about 90 days and beyond 12 months. Cohort B patients not in Cohort A mainly have baseline and longer-term data collected. Participants will have repeated examinations during hospital stays and outpatient visits, including echocardiography and ECG. Researchers will collect clinical data, laboratory samples, and measure outcomes such as clinical deterioration and bleeding within 7 days, plus longer-term outcomes like recurrence of PE, quality of life, and chronic complications. The study will follow patients up to a year or more to assess these outcomes and improve future PE care.

Repeated Examinations for Typing Pulmonary Embolism