Actively Recruiting
Repeated Transcranial Magnetic Stimulation for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Clinical Trial
Led by The First Affiliated Hospital of Soochow University · Updated on 2026-05-12
46
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Objectives: This study aims to evaluate the clinical efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore the potential underlying mechanisms by which rTMS alleviates clinical symptoms in IBS-D patients. Design: This is a clinical trial that uses clinical symptom scales to assess the therapeutic effect of rTMS on IBS-D patients. Meanwhile, gut microbiota and metabolite profiling, as well as the methane-hydrogen breath test, will be applied to investigate the mechanism of action from the perspectives of gut microecology, intestinal motility, and metabolism, so as to provide scientific evidence for the clinical application of rTMS in the treatment of IBS-D.
CONDITIONS
Official Title
Repeated Transcranial Magnetic Stimulation for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 60 years
- Diagnosed with diarrhea-predominant IBS (IBS-D) according to Rome IV criteria
- Recurrent abdominal pain at least one day per week in the last three months
- Symptoms started at least six months before diagnosis
- More than 25% of stools are loose or watery (Bristol Stool Form Scale types 6 or 7)
- Less than 25% of stools are hard or lumpy (types 1 or 2)
- Moderate to severe symptoms with IBS Symptom Severity Scale score above 175
- Stable dietary habits including non-vegetarian options for at least one month before study
- For participants over 50 years, a normal colonoscopy within the past three years is required
You will not qualify if you...
- Completed less than 50% of daily diaries during screening
- History of organic gastrointestinal diseases like inflammatory bowel disease
- Previous gastrointestinal surgery or gallbladder removal
- Helicobacter pylori infection diagnosed within the last two years
- History of gluten or lactose intolerance
- History of cancer
- Neurological or psychiatric disorders
- Severe uncontrolled diseases such as diabetes, thyroid, liver, kidney, or heart failure
- Use of probiotics, antibiotics, prokinetics, antidiarrheals, antidepressants, or immunosuppressants within four weeks
- Pregnancy, breastfeeding, or within 12 months postpartum
- Severe needle phobia, metal allergies, implanted pacemaker, or known allergic conditions
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China, 215006
Actively Recruiting
Research Team
X
Xiuji Kan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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