Actively Recruiting
Reperfusion Treatment in Acute Pulmonary Embolism
Led by Sahlgrenska University Hospital · Updated on 2026-01-21
220
Participants Needed
13
Research Sites
213 weeks
Total Duration
On this page
Sponsors
S
Sahlgrenska University Hospital
Lead Sponsor
S
Stockholm South General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
International guidelines recommend immediate reperfusion with systemic thrombolysis (ST) as first-line treatment in high-risk pulmonary embolism (PE). The therapy improves hemodynamics and overall survival but is also associated with a significant risk of severe bleeding. Catheter-directed intervention (CDI) is recommended as an alternative reperfusion therapy in high-risk PE when ST is contraindicated or has failed, as well as in patients who deteriorate or fail to improve during anticoagulation (AC) treatment. Despite lack of high-quality evidence and randomized studies between CDI and standard care, the use of CDI is spreading rapidly in high-risk PE and in less severe PE not fulfilling current treatment criteria.
CONDITIONS
Official Title
Reperfusion Treatment in Acute Pulmonary Embolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older, including pregnant women, with confirmed acute pulmonary embolism by CTPA, angiography, or scintigraphy
- Planned for or have received catheter-directed intervention or systemic thrombolysis treatment
- Provided informed consent or waiver applies if patient does not survive before consent can be obtained
You will not qualify if you...
- Currently enrolled in another interventional catheter-directed intervention trial
- Primary reperfusion treatment was surgical embolectomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Aarhus University Hospital
Aarhus, Denmark
Actively Recruiting
2
Rigshospitalet
Copenhagen, Denmark
Actively Recruiting
3
Odense University Hospital
Odense, Denmark
Actively Recruiting
4
Sahlgrenska University Hospital
Gothenburg, Sweden, 41345
Actively Recruiting
5
Linköping University Hospital
Linköping, Sweden
Actively Recruiting
6
Sunderby Hospital
Luleå, Sweden
Actively Recruiting
7
Skåne University Hospital
Lund, Sweden
Actively Recruiting
8
Örebro University Hospital
Örebro, Sweden
Actively Recruiting
9
Danderyd Hospital
Stockholm, Sweden
Actively Recruiting
10
Karolinska University Hospital Huddinge
Stockholm, Sweden
Actively Recruiting
11
Karolinska University Hospital Solna
Stockholm, Sweden
Actively Recruiting
12
Södersjukhuset
Stockholm, Sweden
Actively Recruiting
13
Uppsala University Hospital
Uppsala, Sweden
Not Yet Recruiting
Research Team
F
Freyr Einarsson, MD
CONTACT
A
Annika Odenstedt, coordinator
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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