Multicenter Nordic Study Comparing Catheter-Directed Intervention and Systemic Thrombolysis for Acute Pulmonary Embolism

What this Trial Is About

Researchers are studying treatment options for adults with acute pulmonary embolism PE, a serious condition where blood clots block lung arteries. The study compares catheter-directed intervention CDI, which uses devices like mechanical thrombectomy or catheter-directed thrombolysis, to systemic thrombolysis ST with a clot-busting drug called alteplase. This observational study aims to understand how these treatments affect survival and bleeding risks within 30 days after treatment. Participants receive either catheter-directed intervention using various devices or systemic thrombolysis with intravenous alteplase. The FlowTriever device is a common CDI method used in Sweden. The study observes current clinical practices in Nordic countries, including patients who receive standard treatments or alternative reperfusion therapies depending on their condition and available resources. During the study, researchers will collect data on severe bleeding or death within 30 days, as well as other outcomes like recurrent PE, hospital and ICU stay duration, and heart function up to one year. Participants will be monitored through imaging, functional tests, questionnaires on quality of life and breathing difficulties, and blood biomarkers. The study lasts at least one year to evaluate both short- and long-term effects of the treatments.

Reperfusion Treatment in Acute Pulmonary Embolism