Actively Recruiting
Repetitive Transcranial Alternating Current Stimulation (rtACS) for the Treatment of Optic Neuropathies
Led by National Taiwan University Hospital · Updated on 2026-01-30
188
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to see whether repeated transcranial alternating current stimulation can activate impaired retinal ganglion cells and improve both structural and functional outcomes in patients with glaucoma.
CONDITIONS
Official Title
Repetitive Transcranial Alternating Current Stimulation (rtACS) for the Treatment of Optic Neuropathies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be at least 18.
- Clinical diagnosis of glaucoma with Humphrey Visual Field 24-2 mean deviation between -22 dB and -5 dB and Visual Field Index between 10% and 90%.
- Visual field test at screening must have fixation losses ≤ 33%, false-negative rate ≤ 20%, and false-positive rate ≤ 20%.
- Difference in mean deviation between two consecutive visual field tests must be less than 2 dB.
- Best-corrected visual acuity of 0.2 or better in the worse eye selected for treatment.
- If both eyes meet criteria, one eye will be randomly selected for participation.
- Investigator must consider the participant's eye pressure clinically stable.
- Ability to comply with study requirements and complete scheduled visits.
- Understanding and signing of informed consent; document may be read aloud if vision is impaired.
- Optical coherence tomography shows measurable changes in retinal nerve fiber or ganglion cell-inner plexiform layer thickness.
You will not qualify if you...
- History of ocular herpes.
- Pathological nystagmus.
- Retinal disease affecting vision.
- Corneal opacity affecting vision.
- Cataract affecting vision.
- Uveitis or other intraocular inflammatory diseases.
- Implanted electronic devices such as pacemakers.
- Rheumatologic or autoimmune diseases.
- Brain tumor or intracranial magnetic metallic implants.
- History of epilepsy.
- Periocular skin lesions.
- Anxiety with Geriatric Anxiety Scale score above 12.
- History of claustrophobia.
- Participation in another clinical trial within past 3 months involving eye-related medication or training.
- Physical or mental conditions that increase risk or interfere with assessments (e.g., dementia).
- Previous ocular electrical stimulation or visual training within past 12 months.
- Uncontrolled hypertension or diabetes.
- Pregnant or breastfeeding.
- History of craniotomy, burr hole surgery, head trauma, intracranial tumor, vascular malformation, or intracranial surgery.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Taiwan University Hospital
Taipei, Hawaii, Taiwan, 100
Actively Recruiting
Research Team
C
Chien-Chia Su
CONTACT
Y
Yu-Cen Ma
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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