Study of Repetitive Transcranial Magnetic Stimulation for Motor Recovery in Adults with Hemiplegic Stroke

What this Trial Is About

Stroke is a leading cause of death worldwide, and many survivors experience lasting effects such as hemiplegia, or weakness on one side of the body. Current rehabilitation therapies have limited effects, so new treatments are needed. This trial investigates the use of repetitive transcranial magnetic stimulation rTMS, a non-invasive brain stimulation method, to help improve motor recovery in patients with hemiplegic stroke. Participants will be randomly assigned to receive one of three types of rTMS treatments applied to the side of the brain opposite the stroke traditional theta burst stimulation TBS, a modified TBS version, or a sham placebo stimulation. These treatments are based on previous studies and aim to stimulate brain areas to restore function. The study uses a single-blind design to compare these approaches. Throughout the trial, participants will undergo assessments including a keyboard tapping test to measure motor function one day after treatment. The study includes patients at least 18 years old who have had a stroke with motor weakness for more than two weeks. Safety and consent are carefully monitored. The trial is sponsored by Dongtan Sacred Heart Hospital and will continue through December 2040.

Repetitive Transcranial Magnetic Stimulation in Patients With Hemiplegic Stroke