Actively Recruiting
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Led by Peking University First Hospital · Updated on 2025-07-31
568
Participants Needed
3
Research Sites
183 weeks
Total Duration
On this page
Sponsors
P
Peking University First Hospital
Lead Sponsor
T
The First Affiliated Hospital of Air Force Medicial University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD). Repetitive transcranial magnetic stimulation (rTMS) has been used to improve cognitive function in patients with cognitive impairement. This trial is designed to compare the effects of rTMS versus sham intervention on postoperative neurocognitive function in patients with preoperative cognitive impairment.
CONDITIONS
Official Title
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 65 years
- Mild to moderate preoperative cognitive impairment defined by Montreal Cognitive Assessment (MoCA) score between 9 and 26
- Scheduled for elective non-cardiac surgery under general anesthesia lasting more than 2 hours
- Expected hospital stay of at least 5 days after surgery
You will not qualify if you...
- Left-handed
- Education level of primary school or below
- Presence of mental illness, intellectual disability, auditory or visual dysfunction, language impairment, severe neurological disorders, or other conditions preventing evaluation
- Neurosurgery
- Contraindications to rTMS including epilepsy, pregnancy or lactation, or having metal or electric implanted devices such as pacemaker, deep brain stimulator, ventriculoperitoneal shunt, aneurysm clip, cochlear implant, or surgical staples on the scalp
- Other conditions deemed unsuitable for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
2
Peking University Shenzhen Hospital
Shenzhen, Guangzhou, China, 516473
Not Yet Recruiting
3
Xijing Hospital, Air Force Medical University
Xi'an, Shannxi, China, 710032
Not Yet Recruiting
Research Team
D
Dong-Xin Wang, MD, PhD
CONTACT
H
Hao Kong, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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