Study of Repetitive Transcranial Magnetic Stimulation rTMS to Improve Walking and Quality of Life in Adults with Multiple Sclerosis and Spastic Paraparesis

What this Trial Is About

Researchers are studying the effects of repetitive Transcranial Magnetic Stimulation rTMS on walking ability in people with Multiple Sclerosis MS who have spastic paraparesis and moderate walking difficulties. The study aims to measure changes in overall disability, walking endurance, quality of life, and brain activity patterns using EEG. This trial is designed to better understand how rTMS might influence these factors in MS patients. Participants will receive either active rTMS or sham rTMS using a machine that delivers magnetic pulses to specific brain areas. Treatment will occur daily, five days a week, for six consecutive weeks. After a six-week break, all participants will undergo an additional six-week session of active rTMS. The sham treatment uses a lower intensity of magnetic pulses to mimic the procedure without full stimulation. During the study, participants will be assessed on walking speed using the Timed 25-Foot Walk Test over 18 weeks, as well as walking endurance with the Six Minute Walk Test and quality of life measures over 12 weeks. Researchers will monitor neurological stability, medication use, and overall health to ensure safety. The total study period covers these evaluations and treatment phases, with ongoing monitoring for changes in walking ability and quality of life.

Repetitive Transcranial Magnetic Stimulation (rTMS) in MS Induced Spastic Paraparesis