Actively Recruiting
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
Led by Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Updated on 2025-12-09
56
Participants Needed
1
Research Sites
151 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
At present, no drug therapy has been proven to delay the progression of Parkinson's disease (PD). rTMS, as a non-invasive neuromodulation method, can regulate Slow-wave sleep (SWS). SWS is recognized closely related to neurodegeneration. However, there has been no clinical studies on if rTMS could delay the progression of PD by regulating SWS. The main purpose of this study is to explore the changes of SWS in non-rapid eye movement (NREM) sleep period in PD patients by using rTMS, and the relationship with potential improvements of SWS and motor symptom delay. The study aims to find a potential new treatment strategy to delay the neurodegenerative process in PD patients by modulating SWS by rTMS.
CONDITIONS
Official Title
Repetitive Transcranial Magnetic Stimulation(rTMS) Regulating Slow-wave to Delay the Progression of Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with clinically definite or probable Parkinson's disease by MDS 2015 criteria
- Chinese Han ethnicity for three generations
- Age between 50 and 80 years
- Hoehn-Yahr stage 1 to 4
- Stable dose of levodopa therapy for at least three weeks before enrollment and during follow-up
- Right-handed
- Signed written informed consent
You will not qualify if you...
- Parkinsonism other than primary Parkinson's disease
- Prior neurosurgical or stereotaxic brain surgery for Parkinson's or previous TMS treatment
- Cognitive dysfunction (MMSE ≤ 24) or unable to cooperate with assessments
- Mental disabilities
- Pregnant women
- Contraindications to rTMS treatment
- Contraindications to MRI examination
- Sleep disorders like moderate to severe obstructive sleep apnea syndrome or BMI ≥ 30
- Addiction to alcohol or use of medications affecting sleep structure such as SSRIs, TCAs, sedatives, or histamine antagonists
- Unwillingness or inability to consent or participate
- Other reasons deemed inappropriate by the researcher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200040
Actively Recruiting
Research Team
X
Xiaoying Zhu, doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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