Study of Home-Based Repetitive Transorbital Alternating Current Stimulation to Treat Vision Loss in Optic Neuropathy

What this Trial Is About

Researchers are evaluating the effectiveness and feasibility of a home-based treatment called repetitive transorbital alternating current stimulation rtACS to help people with optic neuropathy, a condition causing visual impairment. The study aims to see if this therapy can improve vision and functional independence by slowing or reversing vision loss related to the optic nerve and visual pathways. This open-label study is sponsored by NYU Langone Health and focuses on adults with confirmed optic neuropathy who have specific visual field defects and visual acuity levels. Participants will receive a total of 30 stimulation sessions using the SAVIR Alpha Synch mobile device. The first two sessions will take place in the clinic, with the initial session occurring one day after the baseline visit and the second session 48 hours later. The remaining 28 sessions will be conducted at home every other day over an 8-week period. This home-based intervention is designed to be non-invasive and is intended to stimulate the visual system. During the study, participants will undergo several assessments including measurements of retinal nerve fiber layer thickness, optic nerve head cup-to-disc ratio, visual field scores, visual acuity, contrast sensitivity, and vision-related quality of life questionnaires. These will be evaluated at baseline, 1 week, 3 months, and 6 months post-intervention. Adherence to the treatment schedule will be tracked, and safety monitoring will take place throughout the study. The total participation includes the baseline visit, intervention period, post-intervention visit, and two follow-up visits.

Repetitive Transorbital Alternating Current Stimulation for Optic Neuropathies