Actively Recruiting
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
Led by White River Junction Veterans Affairs Medical Center · Updated on 2026-05-04
240
Participants Needed
9
Research Sites
267 weeks
Total Duration
On this page
Sponsors
W
White River Junction Veterans Affairs Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.
CONDITIONS
Official Title
Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- History of low grade intermediate-risk non-muscle invasive bladder cancer meeting any of the following: multifocal low grade non-invasive urothelial carcinoma of any size; solitary low grade non-invasive urothelial carcinoma larger than 3cm; or recurrent low grade non-invasive urothelial carcinoma
- Willingness to comply with all study procedures and availability for the study duration
- No evidence of recurrence at cystoscopy within 6 months after most recent tumor removal
- Ability to consent in English or Spanish
You will not qualify if you...
- History of total bladder removal (cystectomy)
- History of urinary diversion surgery (such as neo-bladder, colon pouch, or ileal conduit)
- History of muscle-invasive bladder tumor
- Pregnancy or breastfeeding
- History of urothelial carcinoma in ureter or renal pelvis with recurrent upper tract disease, unless recurrence free after nephroureterectomy
- Anatomical issues preventing cystoscopy, such as urethrectomy or urethral stricture
- Inability to provide a urine sample for testing
AI-Screening
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Trial Site Locations
Total: 9 locations
1
West Haven VA Medical Center
West Haven, Connecticut, United States, 06516
Actively Recruiting
2
Bay Pines VA Healthcare System
Bay Pines, Florida, United States, 33744
Actively Recruiting
3
James A. Haley Veterans' Hospital
Tampa, Florida, United States, 33612
Actively Recruiting
4
VA Boston Jamaica Plains Campus
West Roxbury, Massachusetts, United States, 02132
Actively Recruiting
5
VA St.Louis Healthcare System
St Louis, Missouri, United States, 63016
Actively Recruiting
6
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
7
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Active, Not Recruiting
8
UT Southwestern Medical Center
Dallas, Texas, United States, 75235
Actively Recruiting
9
White River Junction Veterans Healthcare System
White River Junction, Vermont, United States, 05009
Actively Recruiting
Research Team
P
Prabhavathi Loganathan, MS
CONTACT
L
Laura Jensen, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
3
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