Actively Recruiting
Replacing Protein Via Enteral Nutrition in Critically Ill Patients
Led by King Abdullah International Medical Research Center · Updated on 2025-09-08
2502
Participants Needed
2
Research Sites
292 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigator will investigate the effect of supplemental enteral protein (1.2 g/kg/day) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge up to ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0.8-1.2 g/kg/day), given in conjunction with similar amounts of stepwise caloric administration in the two groups on all-cause 90-day mortality.
CONDITIONS
Official Title
Replacing Protein Via Enteral Nutrition in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Patient started on enteral nutrition via nasogastric, orogastric, duodenal, PEG, or jejunostomy tubes
- Patient is on invasive mechanical ventilation and unlikely to be discharged from ICU the next day
You will not qualify if you...
- Lack of commitment to full life support or brain death; patients with Do Not Resuscitate orders but ongoing life support commitment can be enrolled
- Receiving any parenteral nutrition in ICU at screening
- Received average protein intake greater than 0.8 g/kg/day in the first 4 ICU days
- Being fed entirely by mouth (eating)
- Pregnancy
- Burn patients
- Prisoners or undergoing forced treatment
- Hepatic encephalopathy or Child C liver cirrhosis
- Inherited amino acid metabolism defects
- Allergies to protein supplements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
King Abdulaziz Medical city
Jeddah, Jeddah, Saudi Arabia, 21423
Actively Recruiting
2
Intensive Care Unit, King Abdulaziz Medical City
Riyadh, Saudi Arabia, 11426
Actively Recruiting
Research Team
Y
Yaseen M Arabi, MD
CONTACT
M
Musharaf Sadat, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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