Daily Ergothioneine Supplement to Restore Levels in Adults with Kidney Failure on Dialysis

What this Trial Is About

This research aims to learn how well a daily ergothioneine supplement replenishes ergothioneine levels in the blood of people with kidney failure who are undergoing dialysis. Dialysis removes harmful chemicals but can also reduce valuable chemicals like ergothioneine, which comes from the diet and is usually low in these patients. The study is led by Stanford University and focuses on people with end-stage renal disease ESRD. Participants in this randomized, triple-blinded study will receive either a daily ergothioneine capsule ranging from 5 mg to 25 mg or a matching placebo for up to 12 weeks. The study compares the effects of the supplement versus placebo on blood levels of ergothioneine during and after treatment. During the study, researchers will measure ergothioneine levels in red blood cells and plasma at multiple time points weeks 1, 2, 4, 8, and 12 while taking the supplement or placebo, and weeks 16 and 20 after stopping treatment. Participants will be monitored for changes in these levels to understand how well the supplement replenishes ergothioneine. The total participation includes both the supplementation period and follow-up after stopping the treatment.

Repletion of Ergothioneine in Patients With Kidney Failure