Actively Recruiting
The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
Led by Royal Marsden NHS Foundation Trust · Updated on 2026-02-12
400
Participants Needed
9
Research Sites
294 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC). Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.
CONDITIONS
Official Title
The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 18
- Previous head and neck squamous cell carcinoma treated with radiotherapy with or without chemotherapy
- Local or regional recurrent, residual, or new primary squamous cell carcinoma of the oropharynx, oral cavity, larynx, or hypopharynx
- Ability to give informed consent for biological sample collection (molecular analysis study only)
You will not qualify if you...
- Nasopharyngeal and cutaneous squamous cell carcinoma of the head and neck
- Thyroid, salivary gland, and non-squamous cell head and neck cancers
- Presence of distant metastasis (M1) or surgically inoperable T4b tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
University Hospitals Derby and Burton
Derby, United Kingdom
Actively Recruiting
2
NHS Lothian
Edinburgh, United Kingdom
Actively Recruiting
3
Western General, Greater Glasgow and Clyde
Glasgow, United Kingdom
Actively Recruiting
4
Aintree Hospital
Liverpool, United Kingdom
Actively Recruiting
5
Head and Neck Unit, Royal Marsden Hospital
London, United Kingdom, SW3 6JJ
Actively Recruiting
6
Northwick Park
London, United Kingdom
Actively Recruiting
7
Oxford University Hospital NHS Foundation Trust
Oxford, United Kingdom
Actively Recruiting
8
Poole Hospital, University Hospitals Dorset
Poole, United Kingdom
Actively Recruiting
9
South Tyneside and Sunderland NHS Foundation Trust
Sunderland, United Kingdom
Completed
Research Team
A
Andrew Williamson
CONTACT
S
Sarah Burton
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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