Actively Recruiting
Research on Clinical Recovery and Maintenance Strategies for CHB
Led by Beijing Municipal Administration of Hospitals · Updated on 2025-01-31
285
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Collect basic information of patients before antiviral treatment and when HBsAg disappears, and divide them into three groups A, B, and C based on baseline anti HBs titers after informed consent. During the follow-up period of all patients, clinical biochemistry, virology (HBVDNA, HBVRNA), serological indicators (HBsAg, anti HBs, HBeAg, anti HBe, HBcrAg, anti HBc), AFP, Fibroscan, liver imaging examinations will be conducted every 3-6 months, and blood samples will be retained for monitoring the frequency of immune cells (pDC, Treg) and the expression of functional molecules, as well as cytokines (IFN - γ, IP-10, IL-10, and TGF - β). Observe the sustained response rate and recurrence rate of virological and serological indicators, as well as the incidence of hepatitis and liver cancer during the follow-up period.
CONDITIONS
Official Title
Research on Clinical Recovery and Maintenance Strategies for CHB
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 65 years old
- Gender is not limited
- Diagnosis of chronic hepatitis B according to 2019 guidelines
- Confirmed interferon treatment resulting in disappearance of HBsAg, negative HBeAg, and HBV DNA below detection limit
- Written informed consent signed
You will not qualify if you...
- Co-infection with hepatitis C virus, hepatitis D virus, or HIV
- Autoimmune liver disease
- Long-term alcohol abuse or use of other liver-damaging drugs
- Mental illness
- Evidence of liver tumors or AFP greater than 100 ng/ml
- Decompensated cirrhosis
- Serious diseases of heart, brain, lungs, kidneys, or other systems preventing long-term follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Ditan Hospital
Beijing, Beijing Municipality, China, 100015
Actively Recruiting
Research Team
L
Lu Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here