Actively Recruiting

Age: 12Years +
All Genders
NCT06504589

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

Led by Nicole Hamblett · Updated on 2025-10-01

400

Participants Needed

68

Research Sites

255 weeks

Total Duration

On this page

Sponsors

N

Nicole Hamblett

Lead Sponsor

W

Washington University School of Medicine

Collaborating Sponsor

AI-Summary

What this Trial Is About

The REACH study is for people with CF who do not take cystic fibrosis transmembrane conductance regulator (CFTR) modulators. The goal of the REACH study is to collect research data, including health data and specimens, from people with CF who do not take CFTR modulators. This data may be used to inform CF research, help design CF clinical trials and support the development of new treatments for people with CF who do not take CFTR modulators. Another goal of this study is to learn about research involvement for people with CF who do not take CFTR modulators, engage them in research, and give them an opportunity to learn about what is involved in participating in a CF research study.

CONDITIONS

Official Title

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

Who Can Participate

Age: 12Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Written informed consent (and assent if applicable) obtained from participant or legal guardian
  • Willing and able to follow the study visit schedule and protocol requirements
  • At least 12 years old at first visit
  • Documented diagnosis of cystic fibrosis with clinical features and either sweat chloride  60 mEq/liter or two disease-causing CFTR gene variants; or one disease-causing mutation plus a second variant and sweat  30 mmol/liter with sponsor permission
  • Clinically stable with no major health changes in the 28 days before first visit
  • Not genetically eligible for CFTR modulators or no use of CFTR modulators in the 28 days before first visit with no plans to start during study
  • No investigational drug use within 90 days before first visit
  • Not enrolled in interventional drug or device trials (long-term safety or behavioral trials allowed)
  • No new chronic therapies started within 28 days before first visit
  • No acute antibiotic or systemic corticosteroid use for respiratory symptoms within 28 days before first visit
Not Eligible

You will not qualify if you...

  • History of lung transplantation
  • Pregnant or planning pregnancy during the 12-month study period (for persons who can become pregnant)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 68 locations

1

The Children's Hospital Alabama, University of Alabama at Birmingham

Birmingham, Alabama, United States, 35233

Actively Recruiting

2

Phoenix Children's Hospital

Phoenix, Arizona, United States, 85016

Actively Recruiting

3

Tucson Cystic Fibrosis Center

Tucson, Arizona, United States, 85724

Actively Recruiting

4

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States, 72205

Actively Recruiting

5

University of California San Diego

La Jolla, California, United States, 92093

Not Yet Recruiting

6

Childrens Hospital Los Angeles

Los Angeles, California, United States, 90027

Actively Recruiting

7

Stanford University Medical Center

Palo Alto, California, United States, 94304

Actively Recruiting

8

University of California, San Francisco - Adult Center

San Francisco, California, United States, 94143

Actively Recruiting

9

University of California, San Francisco - Peds Center

San Francisco, California, United States, 94158

Actively Recruiting

10

Children's Hospital Colorado

Aurora, Colorado, United States, 80045

Actively Recruiting

11

National Jewish Health

Denver, Colorado, United States, 80206

Actively Recruiting

12

University of Florida

Gainesville, Florida, United States, 32610

Actively Recruiting

13

University of Miami

Miami, Florida, United States, 33136

Actively Recruiting

14

Central Florida Pulmonary Group

Orlando, Florida, United States, 32803

Actively Recruiting

15

Tampa General Hospital

Tampa, Florida, United States, 33606

Actively Recruiting

16

Children's Healthcare of Atlanta and Emory University

Atlanta, Georgia, United States, 30329

Actively Recruiting

17

Augusta University

Augusta, Georgia, United States, 30912

Actively Recruiting

18

Saint Luke's Cystic Fibrosis Center of Idaho

Boise, Idaho, United States, 83702

Actively Recruiting

19

Northwestern University

Chicago, Illinois, United States, 60611

Actively Recruiting

20

Riley Hospital for Children

Indianapolis, Indiana, United States, 46202

Actively Recruiting

21

University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

Actively Recruiting

22

University of Kentucky

Lexington, Kentucky, United States, 40506

Actively Recruiting

23

Tulane University

Metairie, Louisiana, United States, 70001

Actively Recruiting

24

John Hopkins Hospital

Baltimore, Maryland, United States, 21287

Not Yet Recruiting

25

Massachusetts General Hospital

Boston, Massachusetts, United States, 02114

Actively Recruiting

26

Boston Children's Hospital

Boston, Massachusetts, United States, 02115

Actively Recruiting

27

University of Massachusetts Memorial Health Care

Worcester, Massachusetts, United States, 01655

Actively Recruiting

28

University of Michigan, Michigan Medicine

Ann Arbor, Michigan, United States, 48109

Actively Recruiting

29

Wayne State University Harper University Hospital

Detroit, Michigan, United States, 48201

Actively Recruiting

30

Corewell Health Helen DeVos

Grand Rapids, Michigan, United States, 49503

Actively Recruiting

31

The Minnesota Cystic Fibrosis Center

Minneapolis, Minnesota, United States, 55455

Actively Recruiting

32

Washington University School of Medicine

St Louis, Missouri, United States, 63110

Actively Recruiting

33

Billings Clinic

Billings, Montana, United States, 59101

Actively Recruiting

34

University of Nebraska Medical Center

Omaha, Nebraska, United States, 69198

Actively Recruiting

35

Morristown Medical Center

Morristown, New Jersey, United States, 07960

Actively Recruiting

36

The Cystic Fibrosis Center of Western New York

Buffalo, New York, United States, 14203

Not Yet Recruiting

37

Cohen Children's Medical Center of New York

New Hyde Park, New York, United States, 11042

Actively Recruiting

38

Columbia University Cystic Fibrosis Program

New York, New York, United States, 10032

Actively Recruiting

39

University of Rochester Medical Center Strong Memorial

Rochester, New York, United States, 14642

Actively Recruiting

40

New York Medical College at Westchester Medical Center

Valhalla, New York, United States, 10595

Actively Recruiting

41

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, United States, 27599

Actively Recruiting

42

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, United States, 27157

Actively Recruiting

43

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States, 45229

Actively Recruiting

44

Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States, 44106

Actively Recruiting

45

Cleveland Clinic Cystic Fibrosis Program

Cleveland, Ohio, United States, 44195

Not Yet Recruiting

46

Nationwide Children's Hospital

Columbus, Ohio, United States, 43205

Actively Recruiting

47

Dayton Children's Hospital

Dayton, Ohio, United States, 45404

Actively Recruiting

48

Oregon Health & Sciences University

Portland, Oregon, United States, 97239

Actively Recruiting

49

Hershey Medical Center Pennsylvania State University

Hershey, Pennsylvania, United States, 17033

Actively Recruiting

50

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

51

University of Pennsylvania

Philadelphia, Pennsylvania, United States, 19104

Actively Recruiting

52

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States, 15224

Actively Recruiting

53

Medical University of South Carolina

Charleston, South Carolina, United States, 29425

Actively Recruiting

54

Prisma Health Children's Hospital - Midlands

Columbia, South Carolina, United States, 29203

Actively Recruiting

55

Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

56

Dell Children's Medical Center of Central Texas

Austin, Texas, United States, 78723

Actively Recruiting

57

University of Texas Southwestern / Children's Health

Dallas, Texas, United States, 75207

Actively Recruiting

58

University of Texas Southwestern

Dallas, Texas, United States, 75390

Actively Recruiting

59

Cook Children's Medical Center

Fort Worth, Texas, United States, 76104

Actively Recruiting

60

Baylor College of Medicine

Houston, Texas, United States, 77030

Actively Recruiting

61

Adult Cystic Fibrosis Center at the University of Utah

Salt Lake City, Utah, United States, 84112

Actively Recruiting

62

Inova L.J. Murphy Pediatric CF Program

Fairfax, Virginia, United States, 22031

Actively Recruiting

63

Virginia Commonwealth University

Richmond, Virginia, United States, 23219

Actively Recruiting

64

Seattle Children's Hospital

Seattle, Washington, United States, 98105

Actively Recruiting

65

University of Washington Medical Center

Seattle, Washington, United States, 98195

Actively Recruiting

66

Providence Medical Group, Cystic Fibrosis Clinic

Spokane, Washington, United States, 99204

Actively Recruiting

67

West Virginia University - Morgantown

Morgantown, West Virginia, United States, 26507

Actively Recruiting

68

University of Wisconsin

Madison, Wisconsin, United States, 53792

Actively Recruiting

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Research Team

O

Olena Boyarska

CONTACT

A

Anna Mead

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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