Actively Recruiting
Efficacy and Safety of Once-weekly Subcutaneous NNC0662-0419 in Participants With Type 2 Diabetes - a Dose-finding Study
Led by Novo Nordisk A/S · Updated on 2026-05-19
270
Participants Needed
63
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effect and safety of different doses of the medicine NNC0662-0419 in adults living with type 2 diabetes. This phase 2 clinical trial compares NNC0662-0419 with placebo and an approved diabetes medication called semaglutide. The goal is to find out if NNC0662-0419 is effective and safe for lowering blood sugar in people with type 2 diabetes. Participants will receive one of three treatments: NNC0662-0419, semaglutide, or placebo. All treatments are given once weekly by injection under the skin. NNC0662-0419 will be given in increasing doses during the study. Semaglutide and placebo will also be given by weekly injections to match the other groups. Treatment assignment is random and participants will not know which treatment they receive. During the study, participants will be monitored regularly for changes in blood sugar levels measured by glycated hemoglobin (HbA1c) at weeks 16, 28, and 40. Additional assessments include body weight, fasting glucose, cholesterol levels, kidney function, waist size, inflammatory markers, and safety through adverse event tracking. The study lasts about 40 weeks of treatment with follow-up to week 44 to evaluate effects and safety.
CONDITIONS
Brief Title
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female (sex at birth)
- Age 18 to 75 years at signing informed consent
- HbA1c between 7.0% and 10.0% as confirmed by central lab at screening
- Willingness to achieve weight loss greater than 25% of baseline weight
You will not qualify if you...
- Use of any diabetes or obesity medication other than allowed short-term insulin within 90 days before screening
- Uncontrolled or unstable diabetic retinopathy or maculopathy
- Known hypoglycaemic unawareness as indicated by Clarke's Questionnaire
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 40 weeks
Participants receive once-weekly subcutaneous injections of NNC0662-0419, semaglutide, or placebo in a dose-escalating manner to lower blood sugar.
Weekly visits for up to 40 weeks
Duration - 4 weeks
Participants are monitored for safety and adverse events after treatment ends.
1 to 2 visits after treatment completion
Trial Site Locations
Total: 63 locations
1
First Valley Medical Group
Lancaster, California, United States, 93534
Actively Recruiting
2
Torrance Clinical Research Institute, Inc.
Lomita, California, United States, 90717
Actively Recruiting
3
Ark Clinical Research
Long Beach, California, United States, 90815
Actively Recruiting
4
Pacific Clinical Studies
Los Alamitos, California, United States, 90720
Actively Recruiting
5
Wetlin Research Associates, Inc.
San Diego, California, United States, 92120
Actively Recruiting
6
Diablo Clinical Research, Inc.
Walnut Creek, California, United States, 94598
Actively Recruiting
7
Encore Medical Research LLC
Hollywood, Florida, United States, 33024
Actively Recruiting
8
Bioclinical Research Alliance
Miami, Florida, United States, 33155
Actively Recruiting
9
South Broward Research LLC
Miramar, Florida, United States, 33027
Actively Recruiting
10
West Orange Endocrinology
Ocoee, Florida, United States, 34761
Not Yet Recruiting
11
Encore Medical Research of Weston
Weston, Florida, United States, 33331
Actively Recruiting
12
Elite Clinical Trials
Blackfoot, Idaho, United States, 83221
Actively Recruiting
13
Cedar-Crosse Research Center
Chicago, Illinois, United States, 60607
Actively Recruiting
14
Brigham & Women's Hospital
Boston, Massachusetts, United States, 02115-5804
Not Yet Recruiting
15
Headlands Research
Springfield, Missouri, United States, 65807
Actively Recruiting
16
PharmQuest
Greensboro, North Carolina, United States, 27408
Actively Recruiting
17
Piedmont Healthcare Statesville
Statesville, North Carolina, United States, 28625
Actively Recruiting
18
Providence Center for Clinical Research
Dayton, Ohio, United States, 45439
Actively Recruiting
19
CNS Healthcare
Memphis, Tennessee, United States, 38119
Actively Recruiting
20
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390-9302
Actively Recruiting
21
JCCT- Juno NW Houston
Houston, Texas, United States, 77040
Actively Recruiting
22
Consano Clinical Research, LLC
Shavano Park, Texas, United States, 78231
Actively Recruiting
23
Frontier Clinical Research - Kingwood
Kingwood, West Virginia, United States, 26537
Not Yet Recruiting
24
Opca bolnica Karlovac
Karlovac, Croatia, 47000
Actively Recruiting
25
Poliklinika SLAVONIJA OSIJEK
Osijek, Croatia, 31000
Actively Recruiting
26
Opca bolnica Varazdin_Endocrinology
Varaždin, Croatia, 42 000
Actively Recruiting
27
Poliklinika Solmed
Zagreb, Croatia, 10000
Actively Recruiting
28
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
Szeged, Csongrád-Csanád, Hungary, 6725
Not Yet Recruiting
29
Debreceni Egyetem
Debrecen, Hajdú-Bihar, Hungary, 4032
Not Yet Recruiting
30
Debreceni Egyetem
Debrecen, Hungary, 4031
Not Yet Recruiting
31
Akaicho Clinic_Diabetes Internal Medicine
Chiba-shi, Chiba, Japan, 260-0804
Actively Recruiting
32
Naka Kinen Clinic_Internal medicine
Ibaraki, Japan, 311-0113
Actively Recruiting
33
Soka Sugiura Internal Medicine Clinic
Soka-shi, Saitama, Japan, 340-0015
Actively Recruiting
34
Tokyo-Eki Center-building Clinic_Internal Medicine
Tokyo, Japan, 103-0027
Actively Recruiting
35
ToCROM Clinic_Internal Medicine
Tokyo, Japan, 160-0008
Actively Recruiting
36
"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik
Bialystok, Podlaskie Voivodeship, Poland, 15-351
Not Yet Recruiting
37
Terpa Sp. z o.o. Sp. k.
Lublin, Poland, 20-333
Not Yet Recruiting
38
Formed 2 Sp. z o.o.
Oświęcim, Poland, 32-600
Actively Recruiting
39
PANSTWOWY INSTYTUT MEDYCZNY MSWiA
Warsaw, Poland, 02-507
Actively Recruiting
40
Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko
Zabrze, Poland, 41-800
Actively Recruiting
41
Casa De Saúde De Santa Filomena S.A._Unidade de Ensaios Clínicos
Coimbra, Portugal, 3000-150
Actively Recruiting
42
Cardiolima Centro Diagnostico Cardio-Pulmonar De Ponte De Lima Lda
Ponte de Lima, Portugal, 4990-029
Actively Recruiting
43
Hospital Trofa Saude Senhor do Bonfim S.A_Unidade de Ensaios Clínicos
Vila do Conde, Portugal, 4480-565
Actively Recruiting
44
Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia
Vila Nova de Gaia, Portugal, 4400-346
Actively Recruiting
45
DIADA, s.r.o.
Bardejov, Slovakia, 08501
Actively Recruiting
46
Metabol KLINIK s.r.o.
Bratislava, Slovakia, 811 08
Actively Recruiting
47
Diacrin s. r. o.
Bratislava, Slovakia, 83101
Actively Recruiting
48
SIN AZUCAR s.r.o.
Malacky, Slovakia, 901 01
Actively Recruiting
49
Korea University Ansan Hospital_Endocrinology
Ansan-si, Gyeonggi-do, South Korea, 15355
Not Yet Recruiting
50
Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, South Korea, 50612
Not Yet Recruiting
51
Nowon Eulji Medical Center, Eulji University_Endocrinology
Seoul, South Korea, 01830
Not Yet Recruiting
52
Kangbuk Samsung Hospital_Endocrinology
Seoul, South Korea, 03181
Not Yet Recruiting
53
Centro de Salud A Estrada
A Estrada, Spain, 36680
Not Yet Recruiting
54
Equip D´Atencio Primaria Barcelona Sardenya
Barcelona, Spain, 08025
Actively Recruiting
55
Hospital Vithas Sevilla
Castilleja de la Cuesta, Spain, 41950
Actively Recruiting
56
Clínica Bofill
Girona, Spain, 17002
Actively Recruiting
57
ABS La Roca del Vallés_Endocrinología
La Roca Del Vallés, Spain, 08430
Actively Recruiting
58
Centro de Saúde Concepción Arenal
Santiago de Compostela, Spain, 15701
Not Yet Recruiting
59
Ramathibodi Hospital
Bangkok, Thailand, 10400
Not Yet Recruiting
60
Siriraj Hospital
Bangkok, Thailand, 10700
Not Yet Recruiting
61
Maharaj Nakorn Chiang Mai
Chiang Mai, Thailand, 50200
Not Yet Recruiting
62
Srinagarind Hospital
Khon Kaen, Thailand, 40002
Not Yet Recruiting
63
Maharat Nakhon Ratchasima Hospital
Nakhon Ratchasima, Thailand, 30000
Not Yet Recruiting
Research Team
N
Novo Nordisk
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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