Myofascial Pain Syndrome in Women with Primary Dysmenorrhea: A Case-Control Study.
Ana Serrano-Imedio, Cesar Calvo-Lobo, Coraima Casañas-Martin...
https://pubmed.ncbi.nlm.nih.gov/36359567/Actively Recruiting
Led by Azusa Pacific University · Updated on 2025-10-07
60
Participants Needed
1
Research Sites
30 weeks
Total Duration
Researchers are studying women with dysmenorrhea, a condition involving painful periods, to see if they have a stronger musculoskeletal and autonomic nervous system response to painful internal stimuli compared to women without this pain. The study also aims to explore how interoceptive awareness, or the ability to sense internal body signals, might affect this relationship. This investigation seeks to better understand pain perception and related body changes in women with this condition. The study involves two groups women with moderate to severe menstrual pain and age-matched controls with mild or no pain. Participants will attend two sessions one for information and preparation, including tracking their menstrual cycle and heart rate variability HRV daily for 30 days, and a lab session where they will receive a controlled visceral pain stimulus. During the lab visit, hip mobility and muscle strength will be measured before and after the pain stimulus, and HRV will be recorded throughout. Participants will fill out questionnaires, perform daily HRV measurements with a phone app, and attend a lab session where detailed physical and physiological assessments occur. The study will measure changes in hip range of motion, muscle strength, and heart rate variability immediately after the pain stimulus. It will also assess interoceptive awareness during testing. The total participation includes daily monitoring for about a month and a single lab visit, with safety and comfort maintained throughout.
CONDITIONS
A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).
M
Megan M Steele, PT, DPT, PhD(c)
J
Jennifer Fernandez, PT, DPT
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Azusa Pacific University
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Experimental Visceral Pain Stimulus Protocol | Current Clinical Assessment for Dysmenorrhea |
|---|---|---|
| What is it? | A protocol in which participants undergo a visceral pain stimulus while their hip mobility, dorsiflexor strength, and heart rate variability are measured before and after the stimulus. | Clinical evaluation typically involves assessment of musculoskeletal function (mobility, strength), and may include autonomic measures such as heart rate variability, but does not use intentional visceral pain induction as part of routine care. |
| Role in trial | This protocol is the sole intervention group used to generate data on musculoskeletal and autonomic changes in response to induced visceral pain. | Musculoskeletal and autonomic assessment is performed as part of clinical workup for women presenting with menstrual pain, aiming to identify comorbid pain syndromes or functional deficits. |
| Primary use | To investigate how an induced visceral pain stimulus alters musculoskeletal function and autonomic activity, providing insight into pain mechanisms in young women. | To evaluate musculoskeletal and autonomic function as part of pain assessment, supporting diagnosis and management of primary dysmenorrhea and related pain syndromes. |
| How it is given/performed | Participants undergo a visceral pain stimulus in a monitored research setting, with physical tests for hip mobility and dorsiflexor strength and measurement of heart rate variability before and after stimulus. | Clinical assessment typically includes physical tests for hip mobility and dorsiflexor strength, and may include measurements of heart rate variability, without use of an experimental pain stimulus. |
| Evidence status | No published results yet; ongoing clinical investigation aims to provide data on physiological changes after induced visceral pain in women with primary dysmenorrhea. | Clinical musculoskeletal evaluation is supported by cross-sectional and observational evidence linking primary dysmenorrhea to functional and myofascial pain, though evidence for specific management strategies is evolving. |
| Important limitations | Single-group design without randomization or comparator. Experimental protocol may not fully reflect real-world clinical conditions. Only women ages 18-36 with regular cycles and without major pelvic pathology included. | Existing clinical assessment practices rarely induce visceral pain for research purposes. Musculoskeletal tests may vary by provider and lack standardized protocols for autonomic measurement in dysmenorrhea. Evidence for their impact on management is still developing. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 30 days
Participants track their menstrual cycle and measure their heart rate variability daily using apps for 30 days starting from the first day of their period.
Daily measurements using apps
Duration - 1 day
Participants attend a lab session where baseline hip extension and heart rate variability are measured. A visceral pain stimulus is applied using a vaginal barostat probe, and hip mobility and dorsiflexor strength are assessed before and after the stimulus.
1 in-person lab session
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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https://pubmed.ncbi.nlm.nih.gov/23370073/Azusa Pacific University
Lead Sponsor