Visceral pain, mechanisms, and implications in musculoskeletal clinical practice.
E A Pacheco-Carroza
https://pubmed.ncbi.nlm.nih.gov/34126503Actively Recruiting
Led by Azusa Pacific University · Updated on 2025-10-07
60
Participants Needed
1
Research Sites
30 weeks
Total Duration
Researchers are studying women with dysmenorrhea, a condition involving painful periods, to see if they have a stronger musculoskeletal and autonomic nervous system response to painful internal stimuli compared to women without this pain. The study also aims to explore how interoceptive awareness, or the ability to sense internal body signals, might affect this relationship. This investigation seeks to better understand pain perception and related body changes in women with this condition. The study involves two groups: women with moderate to severe menstrual pain and age-matched controls with mild or no pain. Participants will attend two sessions: one for information and preparation, including tracking their menstrual cycle and heart rate variability (HRV) daily for 30 days, and a lab session where they will receive a controlled visceral pain stimulus. During the lab visit, hip mobility and muscle strength will be measured before and after the pain stimulus, and HRV will be recorded throughout. Participants will fill out questionnaires, perform daily HRV measurements with a phone app, and attend a lab session where detailed physical and physiological assessments occur. The study will measure changes in hip range of motion, muscle strength, and heart rate variability immediately after the pain stimulus. It will also assess interoceptive awareness during testing. The total participation includes daily monitoring for about a month and a single lab visit, with safety and comfort maintained throughout.
CONDITIONS
A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 30 days
Participants track their menstrual cycle and measure their heart rate variability daily using apps for 30 days starting from the first day of their period.
Daily measurements using apps
Duration - 1 day
Participants attend a lab session where baseline hip extension and heart rate variability are measured. A visceral pain stimulus is applied using a vaginal barostat probe, and hip mobility and dorsiflexor strength are assessed before and after the stimulus.
1 in-person lab session
Total: 1 location
1
Azusa Pacific University
Azusa, California, United States, 91702
Actively Recruiting
M
Megan M Steele, PT, DPT, PhD(c)
J
Jennifer Fernandez, PT, DPT
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
E A Pacheco-Carroza
https://pubmed.ncbi.nlm.nih.gov/34126503Ana Serrano-Imedio, Cesar Calvo-Lobo, Coraima Casañas-Martin...
https://pubmed.ncbi.nlm.nih.gov/36359567Frank F Tu, Aliza E Epstein, Kristen E Pozolo...
https://pubmed.ncbi.nlm.nih.gov/23370073Kylie Tucker, Anna-Karin Larsson, Stina Oknelid...
https://pubmed.ncbi.nlm.nih.gov/22209423Lukas Van Oudenhove, Philip A Kragel, Patrick Dupont...
https://pubmed.ncbi.nlm.nih.gov/33230131Yuval Yacubovich, Noy Cohen, Lea Tene...
https://pubmed.ncbi.nlm.nih.gov/31733762C Brent Wakefield, Amanda Halls, Nicole Difilippo...
https://pubmed.ncbi.nlm.nih.gov/25562458