Actively Recruiting
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Led by Novo Nordisk A/S · Updated on 2026-03-24
480
Participants Needed
103
Research Sites
311 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Etavopivat is a new medicine under development for treating blood disorders like sickle cell disease and thalassaemia. Sickle cell disease and thalassaemia are inherited blood disorders that affect haemoglobin. Haemoglobin is the protein that carries oxygen through the body. This study is looking into how safe treatment with etavopivat is and how well it works over a long period of time. The study will last for up to 264 weeks, but it will end earlier if etavopivat is approved in the participant's country.
CONDITIONS
Official Title
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be currently participating in an etavopivat parent study for sickle cell disease or thalassemia and have completed at least one treatment period.
- Participant must have shown clinical benefit from etavopivat treatment as judged by the investigator.
- Participants with dose reductions or temporary treatment pauses must have been successfully returned to full etavopivat dose before enrolling.
- Participants on hydroxyurea, crizanlizumab, or l-glutamine oral powder at consent may join if doses have been stable as assessed by the investigator, including weight or age adjustments.
- Temporary dose reductions or pauses for medical reasons may be accepted if considered stable by the investigator based on overall health and clinical context.
You will not qualify if you...
- Any disorder unrelated to sickle cell disease or thalassemia that the investigator believes may risk participant safety or protocol compliance.
- Participant withdrew from or permanently stopped treatment in an etavopivat clinical study.
- Participants with permanent dose reductions longer than 28 days or ongoing temporary treatment pauses.
- Use of hemoglobin S polymerization inhibitors during the parent study or anticipated need during this study.
- Use of experimental selectin antagonists during the parent study or anticipated need during this study.
- Use of erythropoietin or other blood growth factors for more than 4 consecutive weeks during the parent study or anticipated need during this study.
- Use of strong cytochrome P450 3A4 inducing medications within 2 weeks before transfer or anticipated need during the study.
- Current participation in any clinical study other than a designated parent etavopivat study or planned participation during this study.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 103 locations
1
Univ of Alabama Birmingham
Birmingham, Alabama, United States, 35233
Active, Not Recruiting
2
Phoenix Children's Hsptl
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
Children's Hospital Los Angeles - Endocrinology
Los Angeles, California, United States, 90027
Active, Not Recruiting
4
Children's Hospital Los Angeles - Endocrinology
Los Angeles, California, United States, 90027
Actively Recruiting
5
UCSF Oakland Benioff ChildHosp
Oakland, California, United States, 94609
Active, Not Recruiting
6
UCSF Oakland Benioff ChildHosp
Oakland, California, United States, 94609
Actively Recruiting
7
Children's Hosp Of Orange
Orange, California, United States, 92868
Completed
8
University Of California Irvine
Orange, California, United States, 92868
Actively Recruiting
9
University of Connecticut
Farmington, Connecticut, United States, 06030
Active, Not Recruiting
10
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Completed
11
Foundation for Sickle Cell Disease Research
Hollywood, Florida, United States, 33023
Actively Recruiting
12
Univ of Miami/SCCC
Miami, Florida, United States, 33136
Completed
13
Emory University School of Medicine
Atlanta, Georgia, United States, 30303
Active, Not Recruiting
14
Children's Healthcare Atlanta
Atlanta, Georgia, United States, 30329
Actively Recruiting
15
Center for Blood Disorders Augusta University
Augusta, Georgia, United States, 30912
Actively Recruiting
16
Univer Of Illinois at Chicago
Chicago, Illinois, United States, 60612
Not Yet Recruiting
17
Children's Hosp-New Orleans
New Orleans, Louisiana, United States, 70118
Completed
18
Boston Medical Center
Boston, Massachusetts, United States, 02118
Active, Not Recruiting
19
Washington University-St.Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
20
NYC Health+Hospitals
Brooklyn, New York, United States, 11203
Actively Recruiting
21
Columbia University Medical Center_New York_0
New York, New York, United States, 10032
Actively Recruiting
22
Columbia University Medical Center_New York_0
New York, New York, United States, 10032
Not Yet Recruiting
23
Weill Cornell Med Coll-NYPH
New York, New York, United States, 10065
Actively Recruiting
24
Jacobi Medical Center
The Bronx, New York, United States, 10461
Active, Not Recruiting
25
Montefiore Medical Center
The Bronx, New York, United States, 10467
Not Yet Recruiting
26
Atrium Levine Children's/Atrium Health
Charlotte, North Carolina, United States, 28204
Not Yet Recruiting
27
Duke University_Durham
Durham, North Carolina, United States, 27705
Actively Recruiting
28
East Carolina Univ-Greenville
Greenville, North Carolina, United States, 27834
Active, Not Recruiting
29
East Carolina University_Greenville
Greenville, North Carolina, United States, 27834
Completed
30
Atrium Health-Wake Forest Bapt
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
31
Cincinnati Child's Hsp Med Ctr
Cincinnati, Ohio, United States, 45229
Active, Not Recruiting
32
Neuro-Behavioral Clinical Research
North Canton, Ohio, United States, 44720
Active, Not Recruiting
33
Medical University Of South Carolina_Charleston
Charleston, South Carolina, United States, 29425
Actively Recruiting
34
Methodist University Hospital
Memphis, Tennessee, United States, 38104
Actively Recruiting
35
Texas Children's Hospital_Houston
Houston, Texas, United States, 77030
Actively Recruiting
36
UT Health University of Texas
Houston, Texas, United States, 77030
Actively Recruiting
37
Virginia Comm Univ Medical Ctr
Richmond, Virginia, United States, 23298
Actively Recruiting
38
Mary Bridge Children's Health
Tacoma, Washington, United States, 98405
Active, Not Recruiting
39
Versiti, CCBD_Milwaukee
Milwaukee, Wisconsin, United States, 53226
Not Yet Recruiting
40
St Pauls Hospital
Vancouver, British Columbia, Canada, V6Z1Y6
Active, Not Recruiting
41
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Active, Not Recruiting
42
University Health Network - Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Active, Not Recruiting
43
CHU Ste-Justine
Montreal, Quebec, Canada, H3T 1C5
Active, Not Recruiting
44
Alexandria University Hospital
Alexandria, Egypt, Egypt, 21131
Not Yet Recruiting
45
Zagazig University Hospital
Alsharkia, Egypt, Egypt, 44519
Not Yet Recruiting
46
Faculty of Medicine Ain Shams Medical Research Institute (MASRI)
Cairo, Egypt, 1181
Not Yet Recruiting
47
Cairo University
Cairo, Egypt, Egypt, 11956
Actively Recruiting
48
Abu El-Reesh El-Mounira Children University Hospital
Cairo, Egypt, Egypt, 4241317
Actively Recruiting
49
Ap-Hp-Hopital Henri Mondor
Créteil, France, 94000
Not Yet Recruiting
50
Hospices Civils de Lyon-Hopital Edouard Herriot
Lyon, France, 69437
Not Yet Recruiting
51
Ap-Hp-Hopital Robert Debre
Paris, France, 75019
Actively Recruiting
52
Ap-Hp-Hopital Robert Debre
Paris, France, 75019
Not Yet Recruiting
53
Charité - Campus Virchow-Klinikum - Klinik für Pädiatrie mit Schwerpunkt Onkologie und Hämatologie
Berlin, Germany, 13353
Not Yet Recruiting
54
Universitätsklinikum Freiburg - Kinder- und Jugendklinik
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
55
Kintampo Health Research Centre (KHRC)
Kintampo, Bono East, Ghana, 27WF+98M
Not Yet Recruiting
56
Ghana Institute of Clinical Genetics, Korle Bu Teaching Hospital (KBTH)
Accra, Ghana, 0
Not Yet Recruiting
57
General Hospital Of Larissa Koutlibaneio And Triantafylleio - Thalassemia and SCD Unit
Larissa, Thessaly, Greece, 41221
Actively Recruiting
58
Hippokration Hospital
Athens, Greece, 11527
Actively Recruiting
59
General University Hospital of Patras
Pátrai, Greece, 26504
Actively Recruiting
60
'Ippokrateio' General Hospital of Thessaloniki
Thessaloniki, Greece, 54642
Actively Recruiting
61
All India Institute of Medical Sciences (AIIMS), Raipur
Raipur, Chhattisgarh, India, 492099
Not Yet Recruiting
62
K.J Somaiya Hospital and Research Centre
Mumbai, Maharashtra, India, 400022
Not Yet Recruiting
63
Victoria Hospital, Bangalore
Bangalore, India, 560002
Not Yet Recruiting
64
Nirmal Hospital Pvt. Ltd.
Gujarat, India, 395002
Not Yet Recruiting
65
Suretech Hospital and Research Centre Ltd.
Maharashtra, India, 440012
Not Yet Recruiting
66
All India Institute of Medical Sciences_Delhi
New Delhi, India, 110029
Not Yet Recruiting
67
Azienda Ospedaliera Universitaria San Luigi Gonzaga - S.C.D.O. Microcitemie e malattie rare ematologiche
Orbassano, Torino, Italy, 10043
Actively Recruiting
68
Azienda Ospedale Universita Padova
Padova, Italy, 35128
Actively Recruiting
69
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy, 27100
Actively Recruiting
70
Gertrude's Children's Hospital
Nairobi, Nairobi County, Kenya, 00509
Not Yet Recruiting
71
KEMRI CRDR Siaya Clinical Research Annex, Country Referral Hospital
Siaya, Siaya County, Kenya, 40600
Not Yet Recruiting
72
KEMRI-Walter-Reed Kericho
Kericho, Kenya, 20200
Not Yet Recruiting
73
Kombewa Clinical Research Centre
Kisumu, Kenya, 1932
Not Yet Recruiting
74
KEMRI Kondele Children Hospital, Kisumu
Kisumu, Kenya, 40100
Actively Recruiting
75
Ahero Clinical Trials Unit
Kisumu, Kenya, 40101
Actively Recruiting
76
American University of Beirut Medical Centre
Hamra, Lebanon, 11-0236
Actively Recruiting
77
Chronic Care Center
Hazmiyeh, Lebanon, 21211
Actively Recruiting
78
Hospital Nini
Tripoli, Lebanon, 1434
Actively Recruiting
79
University of Nigeria Teaching Hospital (UNTH)
Ituku-Ozalla, Enugu State, Nigeria, 400001
Not Yet Recruiting
80
University College Hospital Paediatric Haematology and Oncology Unit, Ibadan
Ibadan, Oyo State, Nigeria, 0000
Not Yet Recruiting
81
University of Abuja Teaching Hospital, Gwagwalada, Abuja
Abuja, Nigeria, 228
Not Yet Recruiting
82
Barau Dikko Teaching Hospital, Kaduna
Kaduna, Nigeria, 800212
Not Yet Recruiting
83
Aminu Kano Teaching Hospital (AKTH)
Kano, Nigeria, 3452
Not Yet Recruiting
84
Lagos University Teaching Hospital, Lagos
Lagos, Nigeria, 102215
Not Yet Recruiting
85
Sultan Qaboos University Hospital
Muscat, Sultanet of Oman/Muscat/Al Khoud, Oman, 123
Actively Recruiting
86
Prince Mohammad Bin Naser Hospital
Jizan, Saudi Arabia, 82943
Not Yet Recruiting
87
King Khalid University Hospital
Riyadh, Saudi Arabia, 12372
Actively Recruiting
88
Hospital Universitario de Cruces
Barakaldo, Spain, 48903
Active, Not Recruiting
89
Hospital Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
90
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
91
Baskent Universitesi Adana
Adana, Turkey (Türkiye), 01250
Not Yet Recruiting
92
Başkent Üniversitesi Adana-Hematoloji
Adana, Turkey (Türkiye), 01250
Actively Recruiting
93
Hacettepe University Hematology
Ankara, Turkey (Türkiye), 06230
Not Yet Recruiting
94
Hacettepe Üniversitesi Hastanesi- Hematoloji
Ankara, Turkey (Türkiye), 06230
Not Yet Recruiting
95
Mersin University Medical Faculty Pediatric Hematology
Mersin, Turkey (Türkiye), 33110
Not Yet Recruiting
96
Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji
Mersin, Turkey (Türkiye), 33110
Actively Recruiting
97
Guy's Hospital - Haematology
London, United Kingdom, SE1 9RT
Actively Recruiting
98
Guy's Hospital
London, United Kingdom, SE1 9RT
Not Yet Recruiting
99
King's College Hospital - Paediatric Research
London, United Kingdom, SE5 9RS
Actively Recruiting
100
Kings College Hospital - Haematology
London, United Kingdom, SE5 9RS
Actively Recruiting
101
Imperial College London
London, United Kingdom, W12 0NN
Actively Recruiting
102
Manchester Royal Infirmary
Manchester, United Kingdom, M13 9WL
Actively Recruiting
103
Royal Hallamshire Hospital
Sheffield, United Kingdom, S10 2JF
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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