Actively Recruiting
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
Led by Dana-Farber Cancer Institute · Updated on 2025-11-21
46
Participants Needed
2
Research Sites
144 weeks
Total Duration
On this page
Sponsors
D
Dana-Farber Cancer Institute
Lead Sponsor
B
Breast Cancer Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program. The names of the study groups in this study are: * Exercise Training Group * Waitlist Control Group
CONDITIONS
Official Title
Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 59 years
- Heterogeneously dense or extremely dense breast tissue (BIRADS 3 or 4) on mammogram within the past 12 months
- Physically inactive, exercising less than 60 minutes per week at moderate or vigorous intensity
- Not pregnant or breastfeeding
- Able to read and speak English
- Provided written informed consent before study procedures
You will not qualify if you...
- Unable to walk 2 blocks at any pace
- History of breast cancer; prior DCIS allowed if not on endocrine therapy and at least one breast not irradiated
- Using oral or implantable hormonal contraceptives, postmenopausal hormone therapy, selective estrogen receptor modulators, or aromatase inhibitors; Mirena or other IUD allowed
- Regular strength training in the past 3 months
- Using weight loss drugs
- Cardiovascular, respiratory, or musculoskeletal conditions that prevent moderate exercise (e.g., unstable angina, recent heart attack, oxygen-dependent lung disease, osteoarthritis needing joint replacement)
- Psychiatric conditions that prevent participation (e.g., untreated major depression, psychosis, substance abuse, severe personality disorder)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Active, Not Recruiting
2
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
Research Team
J
Jennifer Ligibel, MD
CONTACT
A
Anna Tanasijevic, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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