Effects of Different Resistance Training Volumes on Cognitive Function, Physical Health, and Blood Markers in Individuals With Mild Cognitive Impairment

What this Trial Is About

This research investigates the effects of different volumes of resistance training on various health aspects in people with mild cognitive impairment, including cognitive function, oxidative stress, immune response, lipid levels, blood sugar control, liver and muscle function, blood pressure, and physical performance. The study includes both an acute evaluation of single exercise sessions and a longer-term analysis of an eight-week training program. Researchers aim to understand how one or three sets of resistance exercises impact these measures in this population. Participants will take part in two main study phases. First, a cross-over study will have them perform two types of resistance training sessions one week apart one session with one set of exercises and another with three sets. After this, participants will be randomly assigned to groups performing eight weeks of resistance training, either with one set or three sets per exercise, twice weekly with adequate rest between sessions. A separate control group will maintain usual activities without exercise. The exercise routines include warm-up walking, leg press, chest press, sit-to-stand exercises, medicine ball throws, and treadmill walking. Throughout the study, various tests will be conducted before, immediately after, and 72 hours following exercise sessions to assess blood pressure, heart rate, body temperature, muscle strength, and physical function. Cognitive assessments and blood tests will be done before and after the eight-week training to measure changes in brain function, inflammation, oxidative stress, blood lipids, blood sugar control, muscle damage, and physical fitness. The study expects to observe changes in these outcomes to better understand the effects of resistance training on individuals with mild cognitive impairment.

Resistance Training to Individuals for Cognitive Impairment With Dementia