Actively Recruiting
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Led by St. Joseph's Healthcare Hamilton · Updated on 2026-02-03
50
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
Sponsors
S
St. Joseph's Healthcare Hamilton
Lead Sponsor
S
Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, the investigators ask questions about participants' physical and mental health and take blood samples.
CONDITIONS
Official Title
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years old or older
- Moderate to severe depressive symptoms indicated by a score of 18 or above on the HAM-D
- History of childhood adversity before age 18 as indicated by CECA q or ACES q scores
You will not qualify if you...
- PTSD diagnosis from an adult trauma without early life adversity history
- Active mania or psychosis
- Active substance use disorder
- Active suicide risk requiring higher level care
- Current psychotherapeutic treatment within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8P 3R2
Actively Recruiting
Research Team
K
Katerina Dikaios, MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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