Study of the RISE Supportive Care Program Plus Usual Care for Children with Newly Diagnosed High-Risk Neuroblastoma

What this Trial Is About

Researchers are studying whether adding the Pediatric Resource Intervention to Support Equity Pediatric RISE, a new supportive care program focused on income-poverty, can improve outcomes for low-income children with newly diagnosed high-risk neuroblastoma. This randomized Phase II trial compares usual supportive care alone to usual care plus the Pediatric RISE intervention to see if it helps families facing financial hardship during cancer treatment. Participants will be randomly assigned to one of two groups for six months usual supportive care alone or usual care plus Pediatric RISE. Pediatric RISE includes twice-monthly cash assistance delivered via debit card or electronic payment, benefits counseling through video calls to discuss potential loss of means-tested benefits, and ongoing support. Usual supportive care involves access to social workers, resource specialists, and psychosocial oncology teams. Both groups complete surveys at orientation, three months, and six months. During the study, parents or guardians will attend orientation visits either in person, by phone, or virtually, and complete surveys to track financial hardship, psychological distress, and cognitive outcomes. Researchers will measure changes in household material hardship scores from baseline to six months as the primary outcome. The study is expected to enroll about 84 participants and last approximately six months per participant, with ongoing monitoring of supportive care impact on families.

Resource Intervention to Support Equity (RISE) in High-Risk Neuroblastoma