Study on Traditional Chinese Medicine Treatment for Pulmonary Nodules A Multicenter Prospective Cohort Study

What this Trial Is About

Researchers are investigating the effects of traditional Chinese medicine on people with pulmonary nodules, which are small spots found in the lungs during chest scans. This prospective multicenter cohort study involves at least 2244 participants from four research centers who have pulmonary nodules detected by high-resolution chest CT scans and are recommended for follow-up by a multidisciplinary team. The study aims to understand how traditional Chinese medicine impacts the growth or shrinking of these nodules over time. Participants are divided into two groups based on whether they receive traditional Chinese medicine treatment or not. They will be followed for at least two years, and outcomes such as nodule growth, new nodule appearance, or regression are measured at various time points depending on nodule risk levels. Secondary measures include changes in nodule size, density, volume doubling time, internal and external nodule features, as well as assessments of anxiety, depression, and quality of life using standard scales. During the study, participants will undergo regular chest CT scans at scheduled intervals ranging from 3 months to 60 months depending on their nodule risk. They will also complete self-assessment scales for anxiety, depression, and quality of life at multiple time points. Researchers will track changes in the nodules and patients mental well-being to evaluate the potential benefits of traditional Chinese medicine. The study is sponsored by the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine and is expected to continue until the end of 2029.

Respiratory Disease Cohort Studies of Chinese Medicine for Pulmonary Nodule