Actively Recruiting
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Led by University Health Network, Toronto · Updated on 2024-05-21
230
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles. The abdominal muscles help by forcing air out of your lungs during exhalation; whereas the diaphragm, the main muscle used for breathing, contracts to get air into the lungs during inhalation. With mechanical ventilation, respiratory muscles are able to rest and recover while the breathing machine takes over; however, this may cause respiratory muscle weakness. Patients who develop weakness of these muscles may require more assistance from the ventilator and take longer to recover their ability to breathe without assistance. The impact of this phenomenon on long-term outcomes is uncertain. The RESPIRE study is designed to characterize how respiratory muscles change during mechanical ventilation and to evaluate the impact on long term quality of life. An additional objective of this study is to examine novel measures obtained from automated functions of a ventilator, that may better predict success from weaning from mechanical ventilation.
CONDITIONS
Official Title
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older undergoing invasive mechanical ventilation in the ICU within 36 hours of intubation
- Non-invasively ventilated patients in the ICU within 36 hours of starting non-invasive ventilation
- Non-ventilated ICU patients receiving no respiratory support or only oxygen therapy, including high flow nasal cannula
You will not qualify if you...
- Patients expected to be extubated within 24 hours of screening
- Patients who have already undergone a spontaneous breathing trial at screening
- Patients with a previously diagnosed neuromuscular disorder
- Patients on long-term invasive mechanical ventilation before current hospitalization
- Patients who required invasive ventilation in ICU for more than 24 hours during current hospitalization
- Patients previously enrolled in the study
- Patients with challenging post-hospital follow-up, such as those living overseas or without a fixed address
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
Research Team
R
Rongyu (Cindy) Jin
CONTACT
C
Catherine Bellissimo, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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