Actively Recruiting

Phase Not Applicable
Age: 18Years - 45Years
All Genders
NCT07406295

Respiratory Muscle Training to Improve Cerebrovascular and Immune Function

Led by Florida State University · Updated on 2026-02-13

30

Participants Needed

1

Research Sites

117 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively. Additionally, a lack of exercise contributes to poorer brain health. Most individuals feel they do not have time to exercise. There is a need for a quicker type of training that improves brain health. Newly developed breathing exercises could be a time-efficient, cost-effective, and home-based practice to increase brain health. This practice acts as weightlifting for breathing muscles. These new breathing exercises have already been shown to increase heart health. Heart health is linked to brain health; if an intervention helps the heart, it is likely to also help the brain. It is currently unknown if breathing training can improve brain health in younger adults with obesity. The investigators will utilize the same 8-week program shown to improve heart health. Testing will be conducted before and after the breathing training. The first part of the study will determine if breathing exercises help brain health. Obesity also causes inflammation. This is measured via blood but affects the entire body. It is thought to cause some of the negative outcomes of obesity. By lowering inflammation, it is likely to improve overall health. Breathing exercises may reduce inflammation, but more research is required. The second part of this study will determine whether breathing exercises help reduce inflammation. This study will determine if brain health can be improved in adults with obesity. This could help 40% of American adults with obesity to live longer and healthier lives.

CONDITIONS

Official Title

Respiratory Muscle Training to Improve Cerebrovascular and Immune Function

Who Can Participate

Age: 18Years - 45Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Body mass index greater than or equal to 30 kg/m2
  • Waist circumference greater or equal to 88 cm for females and greater than or equal to 102 cm for males
Not Eligible

You will not qualify if you...

  • Not weight stable (less than 5% change in body mass over the past six months)
  • Overt cardiovascular, neurological, renal, liver, and/or metabolic illness such as diabetes mellitus
  • Current or history of uncontrolled Stage 2 hypertension (blood pressure over 140/90 mmHg; anti-hypertensive medications allowed)
  • Diagnosed obstructive sleep apnea
  • Previous bariatric surgery
  • Diagnosis or signs of overt airway diseases
  • Current or recent use of tobacco or nicotine products within the past 6 months
  • Pregnant, lactating, or post-menopausal females (self-reported)
  • Prisoners
  • Recent abdominal surgery or abdominal hernia
  • Asthma patients with very low symptom perception or frequent severe exacerbations
  • Conditions affecting the ear such as a ruptured eardrum
  • Patients with markedly elevated left ventricular end-diastolic volume and pressure
  • Patients with worsening heart failure symptoms after training
  • Individuals currently suffering from cold, sinusitis, or respiratory tract infections

AI-Screening

AI-Powered Screening

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Trial Site Locations

Total: 1 location

1

Florida State University

Tallahassee, Florida, United States, 32303

Actively Recruiting

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Research Team

T

Thomas Bissen, MS

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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