Actively Recruiting
Respiratory Muscle Training to Improve Cerebrovascular and Immune Function
Led by Florida State University · Updated on 2026-02-13
30
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Millions of adults in America have too much body fat, resulting in obesity. Obesity is detrimental to health and causes disease. Obesity reduces brain health, which causes the brain to function less effectively. Additionally, a lack of exercise contributes to poorer brain health. Most individuals feel they do not have time to exercise. There is a need for a quicker type of training that improves brain health. Newly developed breathing exercises could be a time-efficient, cost-effective, and home-based practice to increase brain health. This practice acts as weightlifting for breathing muscles. These new breathing exercises have already been shown to increase heart health. Heart health is linked to brain health; if an intervention helps the heart, it is likely to also help the brain. It is currently unknown if breathing training can improve brain health in younger adults with obesity. The investigators will utilize the same 8-week program shown to improve heart health. Testing will be conducted before and after the breathing training. The first part of the study will determine if breathing exercises help brain health. Obesity also causes inflammation. This is measured via blood but affects the entire body. It is thought to cause some of the negative outcomes of obesity. By lowering inflammation, it is likely to improve overall health. Breathing exercises may reduce inflammation, but more research is required. The second part of this study will determine whether breathing exercises help reduce inflammation. This study will determine if brain health can be improved in adults with obesity. This could help 40% of American adults with obesity to live longer and healthier lives.
CONDITIONS
Official Title
Respiratory Muscle Training to Improve Cerebrovascular and Immune Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Body mass index greater than or equal to 30 kg/m2
- Waist circumference greater or equal to 88 cm for females and greater than or equal to 102 cm for males
You will not qualify if you...
- Not weight stable (less than 5% change in body mass over the past six months)
- Overt cardiovascular, neurological, renal, liver, and/or metabolic illness such as diabetes mellitus
- Current or history of uncontrolled Stage 2 hypertension (blood pressure over 140/90 mmHg; anti-hypertensive medications allowed)
- Diagnosed obstructive sleep apnea
- Previous bariatric surgery
- Diagnosis or signs of overt airway diseases
- Current or recent use of tobacco or nicotine products within the past 6 months
- Pregnant, lactating, or post-menopausal females (self-reported)
- Prisoners
- Recent abdominal surgery or abdominal hernia
- Asthma patients with very low symptom perception or frequent severe exacerbations
- Conditions affecting the ear such as a ruptured eardrum
- Patients with markedly elevated left ventricular end-diastolic volume and pressure
- Patients with worsening heart failure symptoms after training
- Individuals currently suffering from cold, sinusitis, or respiratory tract infections
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Florida State University
Tallahassee, Florida, United States, 32303
Actively Recruiting
Research Team
T
Thomas Bissen, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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