Actively Recruiting
Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
Led by Indiana University · Updated on 2026-03-02
120
Participants Needed
1
Research Sites
300 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
P
Purdue University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
CONDITIONS
Official Title
Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physically active more than 2.5 hours per week
- Diagnosed with Exercise-Induced Laryngeal Obstruction (EILO) by a physician or speech language pathologist (for EILO group)
- Age between 18 and 26 years
- Experience greater difficulty breathing indoors compared to outdoors, worsened at peak exercise and resolving within 1 to 5 minutes after exercise
- Score of 7 or higher on the Dyspnea Index for upper airway breathing symptoms
- Low risk based on modified Physical Activity Readiness Questionnaire (PAR-Q), body mass index, and non-smoking status
- No history of voice disorders, cognitive difficulties, asthma, lung disease, cardiac disease, serious orthopedic injuries, uncontrolled hypertension, illicit drug use, seizure/epilepsy, claustrophobia, or beta blocker use
- No metallic, mechanical, or magnetic implants such as cardiac devices, cochlear implants, prostheses, stents, or deep brain stimulators
- For control group: Physically active more than 2.5 hours per week
- Age between 18 and 26 years
- Low risk based on modified PAR-Q questionnaire, body mass index, and non-smoking status
- No history of voice disorders, cognitive difficulties, asthma, lung disease, cardiac disease, serious orthopedic injuries, uncontrolled hypertension, illicit drug use, seizure/epilepsy, claustrophobia, or beta blocker use
- No metallic, mechanical, or magnetic implants such as cardiac devices, cochlear implants, prostheses, stents, or deep brain stimulators
You will not qualify if you...
- Age younger than 18 years or older than 26 years
- Women who are pregnant or may be pregnant
- Body mass index over 25 kg/m2
- Any positive answer to the 14 questions on the PAR-Q pre-participation questionnaire
- Current smoking
- History of voice disorders, cognitive difficulties, asthma, lung disease, cardiac disease, serious orthopedic injuries, uncontrolled hypertension, illicit drug use, seizure/epilepsy, claustrophobia, or beta blocker use
- Presence of metallic, mechanical, or magnetic implants such as cardiac devices, cochlear implants, prostheses, stents, or deep brain stimulators
- Do not report greater difficulty breathing inside compared to outside that worsens at peak exercise and stops 1-5 minutes after exercise (for EILO group)
- Significant acute or chronic medical, neurological, or other illnesses that could affect safety, study completion, or study goals
AI-Screening
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Trial Site Locations
Total: 1 location
1
Indiana University
Bloomington, Indiana, United States, 47401
Actively Recruiting
Research Team
R
Rita R Patel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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