Actively Recruiting
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Led by University of Texas at Austin · Updated on 2025-08-24
180
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
Sponsors
U
University of Texas at Austin
Lead Sponsor
F
Freespira, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.
CONDITIONS
Official Title
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically elevated anxiety with a score of 8 or higher on the Overall Anxiety Severity and Impairment Scale (OASIS)
- Diagnosed with at least one primary anxiety or trauma-related disorder including generalized anxiety disorder, panic disorder, health anxiety, agoraphobia, social anxiety disorder, posttraumatic stress disorder, acute stress disorder, adjustment disorder with anxious mood, or anxiety disorder not otherwise specified
- No current use of psychotropic medications or stable on current medications for at least 6 weeks
- Age 18 years or older
- Able to arrange transportation to the laboratory for study visits
- Fluent in English
You will not qualify if you...
- History of medical conditions contraindicating participation in fear-provocation or respiratory challenges such as cardiovascular or respiratory disorders, high blood pressure, epilepsy, strokes, seizures, fainting, or pregnancy/lactation
- Currently receiving other psychological treatment for anxiety
- History of suicide attempt within the past 6 months
- History of psychosis within the past 6 months
- History of moderate to severe alcohol or substance use disorder (excluding nicotine) within the past 3 months
- Endorses COVID-19 symptoms during the screening phase
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Texas at Austin
Austin, Texas, United States, 78712
Actively Recruiting
Research Team
M
Michael J Telch, PhD
CONTACT
S
Shristi Saraff
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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