Actively Recruiting
Respiratory Virome Diversity and Baseline Immunity in Healthy Individuals in Shanghai
Led by Ruijin Hospital · Updated on 2024-10-29
300
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study investigates the diversity of the respiratory virome in healthy individuals in Shanghai and its interaction with the host's baseline immune response. The respiratory virome plays a critical role in various diseases, but research on the respiratory virome in healthy individuals in China is limited. This prospective study will analyze the upper and lower respiratory virome and examine the effects of demographic factors such as age, gender, and geographic background. Additionally, a respiratory virome database will be established, and multi-omics approaches will be used to study immune response mechanisms in relation to virome diversity.
CONDITIONS
Official Title
Respiratory Virome Diversity and Baseline Immunity in Healthy Individuals in Shanghai
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20-35 years or 60-75 years, Han ethnicity, any gender
- Body Mass Index between 19-26 kg/m²
- Minimum weight of 50 kg for males and 45 kg for females
- Good overall health determined by medical history, physical exam, vital signs, and recent health checkup
- Female participants must be non-pregnant and non-lactating (for younger group)
- Able to tolerate bronchoscopy and willing to provide nasal and throat swabs, respiratory secretions, and blood samples
- Fully informed about the study and willing to provide written consent and complete questionnaires
- Good compliance and willingness to follow the study protocol and complete follow-up procedures
You will not qualify if you...
- Non-permanent residents of Shanghai who have stayed in the city less than 30 days, or permanent residents who have left the city within the past 30 days
- History of significant illness or major surgery within the past 30 days or planned during the study
- Respiratory diseases requiring medication in the past 30 days
- Presence of significant diseases affecting neurological, cardiovascular, hematologic, hepatic, renal, gastrointestinal, respiratory, metabolic, endocrine, immune, skeletal systems or other conditions unsuitable for study
- Long-term medication use
- Positive tests for HIV, hepatitis B, hepatitis C, or syphilis antibodies
- Participation in any drug or device clinical trial within the past 3 months
- Vaccination within the past 30 days or planned vaccination during the study
- History of malignant tumors (for elderly group)
- Any condition affecting ability to provide consent, follow protocol, or safety as judged by investigator
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200025
Actively Recruiting
Research Team
J
Jiayang Yan, Ph. D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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