Actively Recruiting
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
Led by National Heart Centre Singapore · Updated on 2023-08-02
2000
Participants Needed
1
Research Sites
817 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hypertension and aortic stenosis are the two leading conditions that cause thickening of the heart muscles (left ventricular hypertrophy). Left ventricular hypertrophy is initially adaptive to maintain optimal heart function. Ultimately, heart failure occurs as a result of progressive muscle cell death and scarring (myocardial fibrosis). Dedicated techniques using cardiovascular magnetic resonance imaging (MRI) and novel high-sensitivity cardiac troponin blood assays are potential markers to detect myocardial fibrosis. Although hypertension-related heart disease is very common in Singapore, the significance of myocardial fibrosis is not well understood. In this study, the significance of myocardial fibrosis in 2000 patients with hypertension would be investigated. This will be the largest study using state-of-the-art MRI to examine the importance of myocardial fibrosis in hypertensive heart disease. 1000 participants, with at least 1 year follow-up, will be invited for a repeat assessment.
CONDITIONS
Official Title
Response of the Myocardium to Hypertrophic Conditions in the Adult Population
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years and over
- Physician diagnosed essential hypertension, on at least 1 medication for blood pressure control
- Newly diagnosed hypertension with systolic blood pressure 140mmHg or greater (diastolic 90mmHg or greater) on at least 2 office visits and not yet started on anti-hypertensive medications at time of ambulatory blood pressure monitoring
- Resistant hypertension with persistent systolic blood pressure 140mmHg or greater (diastolic 90mmHg or greater) despite treatment with at least 3 anti-hypertensive medications
You will not qualify if you...
- Known secondary hypertension from renal causes (renal artery stenosis, chronic renal failure), endocrine causes (aldosterone excess, pheochromocytoma, Cushing's syndrome, hyperthyroidism), or cardiac causes (coarctation of the aorta)
- Contraindications to cardiovascular magnetic resonance such as implantable devices, cerebral aneurysm clips, cochlear implants, renal impairment (GFR <30 ml/min/1.73m2), claustrophobia, or pregnancy/breast-feeding
- Limited life expectancy
- On-going unstable medical conditions including hypertensive crisis, acute coronary syndromes, or acute heart failure
- History of coronary artery disease or ischemic heart disease
- History of transient ischemic attacks or cerebrovascular events
- History of atrial fibrillation
- History of heart failure
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National Heart Centre Singapore
Singapore, Singapore, 169609
Actively Recruiting
Research Team
M
Mu Jie Liew
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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