Actively Recruiting
Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer
Led by Fujian Medical University · Updated on 2026-02-19
120
Participants Needed
1
Research Sites
183 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This multicenter observational study aims to evaluate the safety and efficacy of neoadjuvant therapy in patients with locally advanced thyroid cancer, focusing on imaging, biochemical, and pathological responses, as well as short-term surgical outcomes and long-term prognosis.
CONDITIONS
Official Title
Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 14 years or older at enrollment
- ECOG performance status between 0 and 2
- Confirmed thyroid carcinoma including DTC, MTC, PDTC, or ATC
- Locally advanced thyroid cancer defined as clinical stage T4N0-1 at baseline
- Documented potential benefit from surgery if distant metastasis is present
- Presence of at least one measurable lesion per RECIST 1.1 criteria
- Normal function of major organs
- Written informed consent obtained
You will not qualify if you...
- Refusal of tumor tissue biopsy or surgery
- Prior thyroid or major neck surgery
- History of other cancer treatments affecting current plan, including surgery, chemotherapy, radiotherapy, or molecular targeted therapy
- Active concurrent malignancies
- Uncontrolled systemic diseases such as diabetes or hypertension
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fujian Medical University Union Hospital
Fuzhou, Fujian, China, 350001
Actively Recruiting
Research Team
W
Wenxin Zhao, M.D., Ph.D.
CONTACT
Z
Zihan Tang, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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