Study of High-Concentration Capsaicin Patch Treatment for Adults with Peripheral Neuropathic Pain in the Auvergne Rhne Alpes Region

What this Trial Is About

Researchers are evaluating patient profiles to understand which factors, including allodynia, are linked to a better response to pain relief using a high concentration 8% capsaicin patch in people with peripheral neuropathic pain. This regional multicenter prospective cohort study follows patients treated in pain clinics across the Auvergne Rhne Alpes region. All participants will receive routine care involving three applications of the 8% capsaicin patch applied locally for 30 to 60 minutes every three months at months 0, 3, and 6, or until their pain score drops below 4 out of 10. Pain levels are assessed every 1.5 months to monitor response, and additional patches may be provided if pain rises above 4 out of 10 after a response. Participants will complete pain monitoring questionnaires including the Neuropathic Pain Symptom Inventory NPSI and Patients Global Impression of Change PGIC scale at regular intervals throughout the 12-month follow-up. Researchers will measure factors associated with better initial pain desensitization response and track outcomes such as pain relief, relapse, and changes in pain medication use over time.

Response Profiles to High-concentration Capsaicin Desensitization in Patients with Peripheral Neuropathic Pain with or Without Allodynia: a Regional Multicenter Prospective Cohort