Actively Recruiting
Resting-state Imaging and OSteoporosiS
Led by University Hospital, Clermont-Ferrand · Updated on 2026-05-13
66
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will be conducted in 20 postmenopausal healthy volunteers, 20 postmenopausal osteoporotic patients with fracture and 20 postmenopausal osteoporotic women without fracture, in order to compare functional connectivity between brain areas. Participants will complete different questionnaires and tests assessing cognition, quality of life, sleep, physical activity, pain, anxiety and depression. A biological sample will be performed in order to evaluate different markers of bone remodeling. A Resting-state functional magnetic resonance imaging (rs-fMRI) will be realized in order to establish functional connectivity between brain regions.
CONDITIONS
Official Title
Resting-state Imaging and OSteoporosiS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 50 or over with postmenopausal osteoporosis, fractured or not, diagnosed by their rheumatologist
- Able to give informed consent to participate in the research
- Affiliation with the French Social Security
- Women aged 50 or over for healthy volunteers
- Bone densitometry performed as part of the protocol, not suggestive of osteoporosis and validated by investigators for healthy volunteers
- Matched to patients by age, menopausal status, socio-educational level, and manual laterality for healthy volunteers
- Able to give informed consent to participate in the research for healthy volunteers
- Affiliation with the French Social Security for healthy volunteers
- Registration or acceptance of registration in the national register of volunteers participating in Research for healthy volunteers
You will not qualify if you...
- Presence of pacemaker
- Presence of medical devices such as implants or prostheses
- Incompatibility with safety criteria of the medical imaging center for magnetic resonance experiments at 3 Tesla
- Contraindications to MRI without injection, such as proven claustrophobia, hearing aid, pacemaker, or brain clip
- Refusal to be informed in case of accidental discovery of an anomaly during the MRI
- Woman under legal protection or deprived of liberty
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Actively Recruiting
Research Team
L
Lise Laclautre
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
3
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