Actively Recruiting
RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation
Led by National Neuroscience Institute · Updated on 2026-01-26
18
Participants Needed
1
Research Sites
471 weeks
Total Duration
On this page
Sponsors
N
National Neuroscience Institute
Lead Sponsor
A
Agency for Science, Technology and Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients. The NNI Neurosurgery team, together with our collaborators, are expanding our recruitment from our pilot trial named RESTORES: RESToration of Rehabilitative function with Epidural Spinal Stimulation. This study aims to investigate the feasibility of electrical stimulation via a spinal cord stimulator (SCS), which will be implanted into the study subjects, and advanced robotic neurorehabilitation to aid in improving neurological function in patients diagnosed with chronic SCI. An additional 15 patients on top of the 3 ongoing patients, male and female participants, above the age of 21 who have been diagnosed with the condition for more than a year will be recruited for this study over a 2-year period. Rehab sessions will take place pre and post-surgical implant, assessing subject improvements
CONDITIONS
Official Title
RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 21 years old and older
- Chronic motor complete spinal cord injury (AIS classification A or B) for more than one year
- Spinal injury between cervical level 2 (C2) and thoracic level 12 (T12)
- Functional segmental reflexes below the injury level
- Able to participate in the perioperative rehabilitation program as determined by the research team
You will not qualify if you...
- Significant medical conditions increasing surgical risk
- Severe dysautonomia with systolic blood pressure fluctuations below 50 or above 200 mmHg on tilt table testing
- Painful musculoskeletal issues including contractures, unhealed fractures, pressure sores, severe spasticity, or osteoporosis
- Significant psychological problems or ongoing drug abuse
- Pregnancy or breastfeeding
- Progressive spinal cord disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Neuroscience Institute
Singapore, Singapore
Actively Recruiting
Research Team
K
Kai Rui Wan, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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