Actively Recruiting

Phase 2
Age: 18Years - 45Years
FEMALE
NCT07197905

Restoring Iron Deficiency in POTS

Led by Vanderbilt University Medical Center · Updated on 2025-12-11

12

Participants Needed

1

Research Sites

53 weeks

Total Duration

On this page

Sponsors

V

Vanderbilt University Medical Center

Lead Sponsor

D

Dysautonomia International

Collaborating Sponsor

AI-Summary

What this Trial Is About

People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this pilot study is to investigate whether giving iron to people with POTS who have low ferritin levels will increase the red blood cell volume and improve POTS symptoms.

CONDITIONS

Official Title

Restoring Iron Deficiency in POTS

Who Can Participate

Age: 18Years - 45Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18-45 years old.
  • Diagnosis of POTS with sustained heart rate increase of at least 30 bpm within 10 minutes of standing or head-up tilt, or absolute upright heart rate over 120 bpm.
  • Symptoms of orthostatic intolerance for at least 3 months.
  • No other diseases or medications explaining orthostatic tachycardia or symptoms.
  • Serum ferritin less than 50 ng/ml.
  • Patients on fludrocortisone allowed if dose stable for at least one month before enrollment and maintained during study.
Not Eligible

You will not qualify if you...

  • Unable or unwilling to provide consent.
  • Pregnancy.
  • Being chair- or bed-ridden.
  • Unable to hold POTS medications during study procedures.
  • History of active bleeding (other than menstruation).
  • History of hypersensitivity to any iron preparation or recent treatment with IV iron within 6 months.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Autonomic Dysfunction Center/ Vanderbilt University Medical Center

Nashville, Tennessee, United States, 37232

Actively Recruiting

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Research Team

M

Megan Orillion, BSN, RN

CONTACT

L

Luis E Okamoto, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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