Actively Recruiting
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Led by Nigde Omer Halisdemir University · Updated on 2026-03-10
160
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery. Although intraoperative fluid administration is routinely used to prevent spinal-induced hypotension, the optimal fluid strategy remains unclear. Both restrictive and liberal fluid approaches may influence maternal hemodynamics and postoperative outcomes through different physiological mechanisms. This prospective, single-center, randomized controlled trial aims to compare restrictive (≤3 mL/kg/h) and liberal (\>3 mL/kg/h) intraoperative crystalloid fluid strategies in patients undergoing elective cesarean section under spinal anesthesia. The primary outcome is the incidence of PONV within the first 24 hours postoperatively. Secondary outcomes include postdural puncture headache (PDPH), time to first flatus, hypotension frequency, and vasopressor requirements.
CONDITIONS
Official Title
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18-45 years
- ASA physical status II
- Scheduled for elective cesarean section under spinal anesthesia
- Provision of written informed consent
You will not qualify if you...
- Emergency cesarean section
- Preeclampsia or eclampsia
- Known cardiac failure
- Known renal failure
- Known hepatic failure
- Coagulopathy
- Contraindication to spinal anesthesia
- Conversion to general anesthesia
- Major technical complications during spinal anesthesia
- Refusal to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Niğde Ömer Halisdemir University Hospital
Niğde, Merkez, Turkey (Türkiye), 51240
Actively Recruiting
Research Team
P
Pınar Erdoğan, Assoc. Prof.
CONTACT
S
Seval Kılbasanlı, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here