Actively Recruiting
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
Led by Gødstrup Hospital · Updated on 2026-05-07
420
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF). The study will also assess the safety of the intervention and its effects on thirst and quality of life. Patients hospitalized with ADHF will be asked to follow either a thirst-driven fluid-intake strategy or a fluid-restriction strategy during their hospital stay and for one month after discharge.
CONDITIONS
Official Title
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Hospitalized for acute decompensated heart failure as the primary diagnosis with at least one documented symptom of new or worsening heart failure such as dyspnea, fatigue, decreased exercise tolerance, or signs of end-organ hypoperfusion
- Objective evidence of acute decompensated heart failure defined by either at least two physical signs (edema, ascites, pulmonary rales/crackles, increased jugular venous pressure, S3 gallop, rapid weight gain from fluid retention) or one physical sign plus one laboratory, radiological, or invasive finding indicative of ADHF
- Treatment with 40 mg or more intravenous furosemide (or equivalent)
- Enrollment within 24 hours of hospital admission
- Ability to provide informed consent
You will not qualify if you...
- Requirement for ICU-level care or intravenous inotropic/vasopressor therapy at admission
- Blood sodium levels below 125 mmol/L or above 145 mmol/L
- End-stage chronic kidney disease on chronic dialysis or estimated glomerular filtration rate below 15 mL/min/1.73 m2
- Any condition judged by the investigator to make participation unsafe or likely to interfere significantly with following the study protocol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Cardiology, Gødstrup Hospital
Herning, Denmark, 7400
Actively Recruiting
Research Team
A
Anders Hostrup Larsen, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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