Actively Recruiting
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure: a Randomized Trial
Led by Gødstrup Hospital · Updated on 2026-05-07
420
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial studies patients hospitalized with acute decompensated heart failure (ADHF) to compare two fluid intake strategies: a thirst-driven, liberal fluid intake and a fluid restriction strategy. Researchers want to learn if the thirst-driven approach is as effective as the fluid restriction method. The study also evaluates safety, effects on thirst, and quality of life for these patients. Participants will follow either a thirst-driven, liberal fluid intake with no restrictions or a fluid restriction of 1.5 liters per day during their hospital stay and for one month after discharge. The study randomly assigns patients to one of these two behavioral strategies to observe their outcomes. During the study, patients will be monitored from enrollment through one month after discharge. Researchers will measure the time it takes for patients to reach clinical stability, assess thirst distress, evaluate patient-perceived quality of life, and track any treatment-related adverse events. The total participation includes hospital stay and one month of follow-up to thoroughly assess both safety and patient experience.
CONDITIONS
Brief Title
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Hospitalized for acute decompensated heart failure as the primary diagnosis with at least one new or worsening symptom such as shortness of breath, fatigue, or decreased exercise tolerance
- Objective evidence of acute decompensated heart failure, including specific physical signs or laboratory findings
- Treatment with 40 mg or more of intravenous furosemide or equivalent
- Enrollment within 24 hours of hospital admission
- Ability to provide informed consent
You will not qualify if you...
- Need for intensive care or intravenous inotropic or vasopressor therapy at admission
- Sodium levels below 125 mmol/L or above 145 mmol/L
- End-stage chronic kidney disease on dialysis or estimated glomerular filtration rate below 15 mL/min/1.73 m2
- Any condition that would make participation unsafe or strongly affect adherence, as judged by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit (in-person)
Duration - Up to 1 month
Participants follow either a fluid restriction strategy or thirst-driven liberal fluid intake to manage acute decompensated heart failure.
Weekly visits for up to 4 weeks
Duration - 1 month after treatment
Participants are monitored for clinical stability, quality of life, thirst distress, and safety after treatment.
1 follow-up visit
Trial Site Locations
Total: 1 location
1
Department of Cardiology, Gødstrup Hospital
Herning, Denmark, 7400
Actively Recruiting
Research Team
A
Anders Hostrup Larsen, MD, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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