Actively Recruiting
Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke
Led by Fundación EPIC · Updated on 2025-07-28
200
Participants Needed
4
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Several studies have demonstrated that simultaneous treatment with two stentrievers (STs) as rescue treatment is very effective, with high recanalization rates even in this group of patients where other revascularization techniques have failed. There has been no observed increase in hemorrhagic complications. Recently, a prospective study has been published where treatment with two ST has been shown to be effective and safe if used as a first-choice treatment (not as rescue) with a successful recanalization rate (eTICI 2c/3) after the first pass of 69%. These results have been reinforced after the publication of a randomized study that confirms, in vitro, the superiority of using two ST over one.
CONDITIONS
Official Title
Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A new disabling focal neurological deficit compatible with acute cerebral ischemia.
- Any age. Informed consent obtained from the patient or representative.
- NIHSS score 63 6.
- Pre-existing functional clinical status less than or equal to 2 according to the mRS clinical scale.
- Maximum time of 24 hours from symptom onset to arterial puncture.
- TICI 0-1 in the diagnosed TICA, MCA, and BA confirmed by angioCT and angiography.
- ASPECTs score on baseline CT greater than or equal to 6.
- Prior intravenous fibrinolysis administered if indicated according to center protocols.
You will not qualify if you...
- Those described in the usual protocols for mechanical thrombectomy of each hospital.
- Pre-existing functional clinical status greater than 2 according to the mRS clinical scale.
- Patients with tandem lesions of dissection or arteriosclerotic origin located in the extracranial internal carotid artery.
- Initiation of treatment with a different technique than the one described.
- Inability to use a proximal balloon guide catheter.
- Use of aspiration catheter.
- Intracranial atherosclerotic plaque as the cause of occlusion.
- Advanced or terminal disease with a life expectancy of less than 6 months.
- Patient who is participating in another study that may affect this one.
- ASPECTS score less than or equal to 6 on baseline CT.
- Evidence of significant hemorrhage or mass effect with midline shift on baseline CT.
- Patients with occlusions in multiple vascular territories.
- Evidence of intracranial tumor (except for small meningiomas).
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
Alfried Krupp Hospital Ruettenscheid
Essen, Germany
Actively Recruiting
2
Hospital Universitario de Cruces
Barakaldo, Spain, 48903
Actively Recruiting
3
Hospital Universitario Central de Asturias
Oviedo, Spain, 33011
Actively Recruiting
4
Hospital Clínico Universitario de Valladolid
Valladolid, Spain, 47003
Actively Recruiting
Research Team
P
PEDRO VEGA VALDES, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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