Actively Recruiting
RET Inhibitor for Neoadjuvant Therapy in Locally Advanced RET-altered Thyroid Cancer
Led by Fudan University · Updated on 2024-08-02
48
Participants Needed
1
Research Sites
284 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter observational study. Patients receive neoadjuvant therapy with RET inhibitors in the real world, and those who can undergo surgery after neoadjuvant therapy receive surgical treatment. The aim of the study is to determine the efficacy and safety of RET inhibitors for neoadjuvant therapy in locally advanced RET-altered thyroid cancer.
CONDITIONS
Official Title
RET Inhibitor for Neoadjuvant Therapy in Locally Advanced RET-altered Thyroid Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients voluntarily join this study and sign an informed consent form
- Age 14 years or older, any gender
- Locally advanced thyroid cancer diagnosed by histopathology, including papillary, medullary, follicular, poorly differentiated thyroid carcinoma, etc
- RET alterations including fusion and mutations
- Locally advanced thyroid cancer meeting at least one of: estimated surgical difficulty with inability to achieve R0/1 resection; T4 thyroid cancer with tumor or lymph node infiltration beyond thyroid capsule; resectable probability less than 80% based on CT imaging
- At least one measurable lesion
- For patients with distant metastasis, surgical benefit must be determined by researchers
- Willing to undergo tumor tissue biopsy or surgery during enrollment and withdrawal
- Normal function of major organs
You will not qualify if you...
- Previous use of RET inhibitors
- Multiple factors affecting oral medication absorption, such as inability to swallow, nausea, vomiting, chronic diarrhea, or intestinal obstruction
- Refusal to undergo tumor tissue biopsy or surgery
- Unsuitable for RET inhibitors or surgery
AI-Screening
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Trial Site Locations
Total: 1 location
1
Fudan Univeristy Shanghai Cancer Center
Shanghai, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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