Preventing Retinal Detachment in Stickler Syndrome Using the OSCSS Laser Procedure A Study Comparing Treated and Untreated Eyes

What this Trial Is About

Researchers are evaluating the OSCSS prophylactic laser retinopexy procedure to prevent retinal detachment in people with Stickler syndrome, including both children and adults. This trial aims to provide standardized, prospective documentation of how well the OSCSS procedure works compared to the natural progression of Stickler syndrome. The research addresses a lack of uniform treatment standards and builds on retrospective evidence suggesting laser prophylaxis can greatly reduce retinal detachment risk in this population. Participants will receive the OSCSS procedure, which involves applying 1500 to 2500 moderate intensity laser burns in an encircling grid pattern on the retina using indirect ophthalmoscopy. The procedure targets the area near the ora serrata extending between the vortex vein ampullae. During the study, participants may have the procedure in one or both eyes. The study will track outcomes over five years and collect untreated eye data if available. Genetic testing for Stickler syndrome will be performed as needed. Participants will attend nine visits over five years for eye tests and checkups, which include photographic fundus mapping, intraocular pressure measurements, vision acuity testing, and other detailed eye evaluations. Researchers will monitor the number of participants developing retinal detachment, size and frequency of retinal defects, adverse events, visual acuity changes, and any surgical interventions needed. The study uses historical control data from a large Stickler syndrome database to compare results and ensure rigorous safety and efficacy documentation over the entire follow-up period.

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)